Evidence map›Paper›PMID 36235137›Full record

ArticleMolecules (Basel, Switzerland)2022

The Influence of the Polymer Type on the Quality of Newly Developed Oral Immediate-Release Tablets Containing Amiodarone Solid Dispersions Obtained by Hot-Melt Extrusion.

Ancuța Cătălina Fița, Ana Andreea Secăreanu, Adina Magdalena Musuc, Emma Adriana Ozon, Iulian Sarbu, Irina Atkinson, Adriana Rusu, Erand Mati, Valentina Anuta, Anca Lucia Pop

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ancuța Cătălina FițaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania.ORCID 0000-0002-4705-4204
Ana Andreea SecăreanuDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania.
Adina Magdalena Musuc"Ilie Murgulescu" Institute of Physical Chemistry, Romanian Academy, 202 Spl. Independentei, 060021 Bucharest, Romania.ORCID 0000-0002-6935-8065
Emma Adriana OzonDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania.
Iulian SarbuDepartment of Pharmaceutical Physics and Biophysics, Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy, "Titu Maiorescu" University, 004051 Bucharest, Romania.ORCID 0000-0002-2259-647X
Irina Atkinson"Ilie Murgulescu" Institute of Physical Chemistry, Romanian Academy, 202 Spl. Independentei, 060021 Bucharest, Romania.
Adriana Rusu"Ilie Murgulescu" Institute of Physical Chemistry, Romanian Academy, 202 Spl. Independentei, 060021 Bucharest, Romania.
Erand MatiDepartment of Pharmaceutical Technology, Faculty of Pharmacy, "Titu Maiorescu" University, 004051 Bucharest, Romania.
Valentina AnutaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania.ORCID 0000-0003-1266-5862
Anca Lucia PopDepartment of Clinical Laboratory and Food Safety, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020956 Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aims to demonstrate the influence of the polymer-carrier type and proportion on the quality performance of newly developed oral immediate-release tablets containing amiodarone solid dispersions obtained by hot-melt extrusion. Twelve solid dispersions including amiodarone and different polymers (PEG 1500, PEG 4000; PEG 8000, Soluplus

Indexed as

AmiodaroneBiological ProductsDrug CompoundingExcipientsPoloxamerPolyethylene GlycolsPolymersPolyvinylsPowdersSolubilityTabletsAmiodaroneBiological ProductsExcipientsPoloxamerpolyethylene glycol 4000Polyethylene GlycolsPolymerspolyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymerPolyvinylsPowdersTabletsamiodarone hydrochloridehot-melt extrusionoral immediate release tabletssolid dispersions

Identifiers

PMID36235137
PMCPMC9573735

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.