Evidence map›Paper›PMID 36235029›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis, Docking Studies and Pharmacological Evaluation of Serotoninergic Ligands Containing a 5-Norbornene-2-Carboxamide Nucleus.

Rosa Sparaco, Ewa Kędzierska, Agnieszka A Kaczor, Anna Bielenica, Elisa Magli, Beatrice Severino, Angela Corvino, Ewa Gibuła-Tarłowska, Jolanta H Kotlińska, Giorgia Andreozzi and 11 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 3 countries.

Rosa SparacoDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.
Ewa KędzierskaDepartment of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodzki St., 20-093 Lublin, Poland.
Agnieszka A KaczorDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0001-8679-9623
Anna BielenicaChair and Department of Biochemistry, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
Elisa MagliDipartimento di Sanità Pubblica, Università Degli Studi di Napoli Federico II, Via Pansini, 5, 80131 Napoli, Italy.
Beatrice SeverinoDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0002-3887-8869
Angela CorvinoDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0002-0617-156X
Ewa Gibuła-TarłowskaDepartment of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0001-7791-0633
Jolanta H KotlińskaDepartment of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodzki St., 20-093 Lublin, Poland.ORCID 0000-0002-4178-1515
Giorgia AndreozziDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.
Paolo LucianoDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.
Elisa PerissuttiDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0002-1754-1191
Francesco FrecenteseDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0001-8821-2937
Marcello CasertanoDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0001-5037-712X
Anna LeśniakCentre for Preclinical Research and Technology, Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 1b Banacha Str., 02-097 Warsaw, Poland.
Magdalena Bujalska-ZadrożnyCentre for Preclinical Research and Technology, Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 1b Banacha Str., 02-097 Warsaw, Poland.
Małgorzata OziębłoCentre for Preclinical Research and Technology, Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, 1b Banacha Str., 02-097 Warsaw, Poland.
Raffaele CapassoDipartimento di Agraria, Università di Napoli Federico II Via Università, 80055 Portici, Italy.ORCID 0000-0002-3335-1822
Vincenzo SantagadaDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.
Giuseppe CaliendoDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.
Ferdinando FiorinoDipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano, 80131 Napoli, Italy.ORCID 0000-0001-7357-5751
University of Naples Federico II · ITMedical University of Lublin · PLMedical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new series of 5-norbornene-2-carboxamide derivatives was prepared and their affinities to the 5-HT

Indexed as

Receptors, SerotoninSerotoninLigandsMolecular Docking SimulationNorbornanesPiperazineReceptor, Serotonin, 5-HT1AStructure-Activity Relationship2-norborneneLigandsNorbornanesPiperazineReceptor, Serotonin, 5-HT1AReceptors, SerotoninSerotonin5-HT1A5-HT2A and 5-HT2C receptor ligands5-norbornene-2-carboxilic acidarylpiperazine derivativesserotonin

Identifiers

PMID36235029
PMCPMC9572521
OpenAlexW4303954622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.