Applications of Single-Molecule Vibrational Spectroscopic Techniques for the Structural Investigation of Amyloid Oligomers.

Katrin Ha Phuong Vu, Gerhard Heinrich Blankenburg, Leonardo Lesser-Rojas, Chia-Fu Chou

Abstract readReview

In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Nanoscale AC Electroosmotic Flow and the Frequency-Size Scaling Observed beyond the Charge Relaxation Regime.Nano letters · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katrin Ha Phuong VuNanoscience and Technology Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan.

Gerhard Heinrich BlankenburgNanoscience and Technology Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan.

Leonardo Lesser-RojasResearch Center for Atomic, Nuclear and Molecular Sciences, University of Costa Rica, San Pedro de Montes de Oca, San José 2060, Costa Rica.ORCID 0000-0003-4057-9486

Chia-Fu ChouInstitute of Physics, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-0070-5556

Funding

Academia Sinica AS-IA-109-M04AFOSR FA2386-21-1-4070AFOSR FA9550-21-1-0430Ministry of Science and Technology 110-2124-M-001-003

6 · The paper itself

Abstract

Amyloid oligomeric species, formed during misfolding processes, are believed to play a major role in neurodegenerative and metabolic diseases. Deepening the knowledge about the structure of amyloid intermediates and their aggregation pathways is essential in understanding the underlying mechanisms of misfolding and cytotoxicity. However, structural investigations are challenging due to the low abundance and heterogeneity of those metastable intermediate species. Single-molecule techniques have the potential to overcome these difficulties. This review aims to report some of the recent advances and applications of vibrational spectroscopic techniques for the structural analysis of amyloid oligomers, with special focus on single-molecule studies.

Indexed as

AmyloidAmyloidosisAmyloid beta-PeptidesAmyloidogenic ProteinsHumansVibrationAmyloidAmyloid beta-PeptidesAmyloidogenic Proteinsamyloid intermediatesamyloid oligomersprotein structuresingle moleculevibrational spectroscopy

Identifiers

PMID36234985

DOI10.3390/molecules27196448

PMCPMC9573641

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