Evidence map›Paper›PMID 36234908›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety.

Amr S Abouzied, Jehan Y Al-Humaidi, Abdulrahman S Bazaid, Husam Qanash, Naif K Binsaleh, Abdulwahab Alamri, Sheikh Muhammad Ibrahim, Sobhi M Gomha

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Novel furo[2,3-RSC medicinal chemistry · 2025
    Article
  10. Review
  11. Article
  12. Biological Activities and Phytochemical Screening ofInternational journal of molecular sciences · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Synthesis of Heteroaromatic Compounds.Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amr S AbouziedDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.ORCID 0000-0002-9202-3909
Jehan Y Al-HumaidiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0002-4920-9791
Abdulrahman S BazaidDepartment of Medical Laboratory Science, College of Applied Medical Sciences, University of Hail, Hail 55476, Saudi Arabia.ORCID 0000-0002-5884-0278
Husam QanashDepartment of Medical Laboratory Science, College of Applied Medical Sciences, University of Hail, Hail 55476, Saudi Arabia.ORCID 0000-0002-3068-0313
Naif K BinsalehDepartment of Medical Laboratory Science, College of Applied Medical Sciences, University of Hail, Hail 55476, Saudi Arabia.ORCID 0000-0001-9001-6361
Abdulwahab AlamriDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 55211, Saudi Arabia.ORCID 0000-0001-8852-7517
Sheikh Muhammad IbrahimChemistry Department, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia.ORCID 0000-0002-3995-8940
Sobhi M GomhaChemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.ORCID 0000-0002-7739-2837

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity. The starting 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2

Indexed as

Antineoplastic AgentsThiadiazolesAnticonvulsantsDrug Screening Assays, AntitumorErbB ReceptorsHarmineHumansMolecular Docking SimulationMolecular StructurePhenylthioureaPyridinesStructure-Activity RelationshipThiazoles1,3,4-thiadiazoleAnticonvulsantsAntineoplastic AgentsErbB ReceptorsHarminePhenylthioureaPyridinesThiadiazolesThiazoles1,3,4-thiadiazoles1,3-thiazolesanticancer activityhydrazonoyl halidesmolecular dockingpyridines

Identifiers

PMID36234908
PMCPMC9572991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.