ArticleMolecules (Basel, Switzerland)2022
Hydrogel Dressing Containing Basic Fibroblast Growth Factor Accelerating Chronic Wound Healing in Aged Mouse Model.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Medicated and multifunctional composite alginate-collagen-hyaluronate based scaffolds prepared using two different crosslinking approaches show potential for healing of chronic wounds.Drug delivery and translational research · 2025Article
- Advanced biomaterial strategies for overcoming age-associated wound healing impairments.APL bioengineering · 2025Review
- Naturally derived hydrogels for wound healing.Therapeutic delivery · 2025Review
- Conditioned medium of engineering macrophages combined with soluble microneedles promote diabetic wound healing.PloS one · 2025Article
- Concomitant heparin use promotes skin graft donor site healing by basic fibroblast growth factor: A pilot prospective randomized controlled study.Contemporary clinical trials communications · 2024Article
- Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system.Drug delivery · 2024Review
- Curcumin loaded hydrogel with double ROS-scavenging effect regulates microglia polarization to promote poststroke rehabilitation.Materials today. Bio · 2024Article
- Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing.Archives of dermatological research · 2024Review
- Development of a Sprayable Hydrogel-Based Wound Dressing: An In Vitro Model.Gels (Basel, Switzerland) · 2024Article
- Release of natural extracts from PVA and PVA-CMC hydrogel wound dressings: a power law swelling/delivery.Frontiers in bioengineering and biotechnology · 2024Article
- Functional drug-delivery hydrogels for oral and maxillofacial wound healing.Frontiers in bioengineering and biotechnology · 2023Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Due to the decreasing self-repairing ability, elder people are easier to form chronic wounds and suffer from slow and difficult wound healing. It is desirable to develop a novel wound dressing that can accelerate chronic wound healing in elderly subjects to decrease the pain of patients and save medical resources. In this work, Heparin and basic fibroblast growth factor(bFGF) were dissolved in the mixing solution of 4-arm acrylated polyethylene glycol and dithiothreitol to form hydrogel dressing in vitro at room temperature without any catalysts, which is convenient and easy to handle in clinic application. In vitro re-lease test shows the bFGF could be continuously released for at least 7 days, whereas the dressing surface integrity maintained for 3 days degradation in PBS solution. Three groups of treatments including bFGF-Gel, bFGF-Sol and control without any treatment were applied on the full-thickness wound on the 22 months old mice back. The wound closure rate and histological and immunohistochemical staining all illustrated that bFGF-Gel displayed a better wound healing effect than the other two groups. Thus, as-prepared hydrogel dressing seems supe-rior to current clinical treatment and more effective in elderly subjects, which shows promising potential to be applied in the clinic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.