Evidence map›Paper›PMID 36234794›Full record

ArticleMolecules (Basel, Switzerland)2022

Site-Specific Radioiodination of Oligonucleotides with a Phenolic Element in a Programmable Approach.

Haitao Zhao, Yu Qin, Dunfang Liu, Xinyao Geng, Cheng Wang, Ding Ding, Xuan Ding, Qian Xia, Jianjun Liu, Ruowen Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haitao ZhaoInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Yu QinInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Dunfang LiuInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Xinyao GengInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Cheng WangInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Ding DingInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Xuan DingInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Qian XiaInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Jianjun LiuInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Ruowen WangInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Weihong TanInstitute of Molecular Medicine (IMM), Institute of Clinical Nuclear Medicine, Department of Nuclear Medicine, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Funding

National Natural Science Foundation of China 21877079
6 · The paper itself

Abstract

Radioiodination of oligonucleotides provides an extra modality for nucleic acid-based theranostics with potential applications. Herein, we report the design and synthesis of a phosphoramidite embedded with a phenolic moiety and demonstrate that oligonucleotides can be readily functionalized with phenol as a precursor by general DNA synthesis. It was identified that the introduction of the precursor does not block the specificity of an aptamer, and the radioiodination is applicable to both DNA and RNA oligonucleotides in a site-specific approach with a commercial kit.

Indexed as

Nucleic AcidsOligonucleotidesDNAIodine RadioisotopesPhenolsRNADNAIodine RadioisotopesNucleic AcidsOligonucleotidesPhenolsRNAaptameroligonucleotidephosphoramiditeradioiodinationsolid-phase synthesis

Identifiers

PMID36234794
PMCPMC9571250

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.