Evidence map›Paper›PMID 36234774›Full record

ArticleMolecules (Basel, Switzerland)2022

Design, Synthesis, and Biological Evaluation of Novel Dihydropyridine and Pyridine Analogs as Potent Human Tissue Nonspecific Alkaline Phosphatase Inhibitors with Anticancer Activity: ROS and DNA Damage-Induced Apoptosis.

Nazeer Ahmad Khan, Faisal Rashid, Muhammad Siraj Khan Jadoon, Saquib Jalil, Zulfiqar Ali Khan, Raha Orfali, Shagufta Perveen, Areej Al-Taweel, Jamshed Iqbal, Sohail Anjum Shahzad

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Serum alkaline phosphatase elevation as a preoperative sarcopenic biomarker in digestive cancer: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  4. Review
  5. Review
  6. Current status ofRSC advances · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nazeer Ahmad KhanDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, University Road, Abbottabad 22060, Pakistan.
Faisal RashidCentre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.ORCID 0000-0003-0123-0505
Muhammad Siraj Khan JadoonCentre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Saquib JalilCentre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Zulfiqar Ali KhanDepartment of Chemistry, Government College University, Faisalabad 38000, Pakistan.
Raha OrfaliDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Shagufta PerveenDepartment of Chemistry, School of Computer, Mathematical and Natural Sciences, Morgan State University, Baltimore, MD 21251, USA.ORCID 0000-0002-3318-9861
Areej Al-TaweelDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Jamshed IqbalCentre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Sohail Anjum ShahzadDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, University Road, Abbottabad 22060, Pakistan.ORCID 0000-0002-4226-3023

Funding

Higher Education Commission 20-12065/NRPU/R&D/HEC/2020 and 5290/Federal/NRPU/R&D/HEC/2016King Saud University RSP2022R431
6 · The paper itself

Abstract

Small molecules with nitrogen-containing scaffolds have gained much attention due to their biological importance in the development of new anticancer agents. The present paper reports the synthesis of a library of new dihydropyridine and pyridine analogs with diverse pharmacophores. All compounds were tested against the human tissue nonspecific alkaline phosphatase (

Indexed as

Antineoplastic AgentsDihydropyridinesAlkaline PhosphataseApoptosisCell ProliferationDNA DamageDrug Screening Assays, AntitumorHumansLevamisoleMolecular Docking SimulationMolecular StructureNitrogenPyridinesReactive Oxygen SpeciesStructure-Activity RelationshipAlkaline PhosphataseAntineoplastic AgentsDihydropyridinesLevamisoleNitrogenPyridinesReactive Oxygen Speciesalkaline phosphataseanticancer activityapoptosis (flow cytometryCDK4/6dihydropyridinesPI and DAPI)pyridinesROS

Identifiers

PMID36234774
PMCPMC9570995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.