Evidence map›Paper›PMID 36234739›Full record

ArticleMolecules (Basel, Switzerland)2022

Oxymatrine Alleviates Gentamicin-Induced Renal Injury in Rats.

Songyao Kang, Tingting Chen, Zhihui Hao, Xiao Yang, Mingfa Wang, Zhifang Zhang, Sijia Hao, Fengting Lang, Hongxia Hao

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Nutrients · 2023
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Songyao KangChinese Veterinary Medicine Innovation Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Tingting ChenChinese Veterinary Medicine Innovation Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Zhihui HaoChinese Veterinary Medicine Innovation Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Xiao YangChinese Veterinary Medicine Innovation Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Mingfa WangQingdao University Medical Group Juxian Hospital, Qingdao 276599, China.
Zhifang ZhangCollege of Traditional Medicine, Inner Mongolia Medical University, Hohhot 010059, China.
Sijia HaoCollege of Traditional Medicine, Inner Mongolia Medical University, Hohhot 010059, China.
Fengting LangChinese Veterinary Medicine Innovation Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Hongxia HaoChinese Veterinary Medicine Innovation Center, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
China Agricultural University · CNInner Mongolia Medical University · CNQingdao Agricultural University · CNQingdao University · CN

Funding

Increase or decrease of major central projects at the same level 2060302National Natural Science Foundation of China 32172897
6 · The paper itself

Abstract

Gentamicin is an aminoglycoside antibiotic commonly used to treat Gram-negative bacterial infections that possesses considerable nephrotoxicity. Oxymatrine is a phytochemical with the ability to counter gentamicin toxicity. We investigated the effects and protective mechanism of oxymatrine in rats. The experimental groups were as follows: Control, Oxymatrine only group (100 mg/kg/d), Gentamicin only group (100 mg/kg/d), Gentamicin (100 mg/kg/d) plus Oxymatrine (100 mg/kg/d) group (

Indexed as

GentamicinsNF-E2-Related Factor 2AcetylglucosaminidaseAlkaloidsAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsCaspase 9CatalaseCreatineGlutathioneKidneyMalondialdehydeMatrinesNF-kappa BNitric OxideAcetylglucosaminidaseAlkaloidsAnti-Bacterial AgentsAnti-Inflammatory AgentsCaspase 9CatalaseCreatineGentamicinsGlutathioneMalondialdehydeMatrinesNF-E2-Related Factor 2NF-kappa BNitric OxideNitric Oxide Synthase Type IIoxymatrineProto-Oncogene Proteins c-bcl-2QuinolizinesSuperoxide DismutasegentamicinnephrotoxicityNrf2/HO-1oxidative stressoxymatrine

Identifiers

PMID36234739
PMCPMC9571404
OpenAlexW4296642229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.