Evidence map›Paper›PMID 36234688›Full record

ArticleMolecules (Basel, Switzerland)2022

Chemoenzymatic Synthesis of Select Intermediates and Natural Products of the Desferrioxamine E Siderophore Pathway.

Katherine M Hoffmann, Jason S Kingsbury, Nathan L March, Yoojin Jang, James H Nguyen, Miranda M Hutt

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katherine M HoffmannDepartment of Chemistry, Swenson Science Center, California Lutheran University, 60 West Olsen Rd. #3700, Thousand Oaks, CA 91360, USA.ORCID 0000-0001-9492-7533
Jason S KingsburyDepartment of Chemistry, Swenson Science Center, California Lutheran University, 60 West Olsen Rd. #3700, Thousand Oaks, CA 91360, USA.ORCID 0000-0001-7722-0069
Nathan L MarchDepartment of Chemistry, Swenson Science Center, California Lutheran University, 60 West Olsen Rd. #3700, Thousand Oaks, CA 91360, USA.
Yoojin JangDepartment of Chemistry, Swenson Science Center, California Lutheran University, 60 West Olsen Rd. #3700, Thousand Oaks, CA 91360, USA.
James H NguyenDepartment of Chemistry, Swenson Science Center, California Lutheran University, 60 West Olsen Rd. #3700, Thousand Oaks, CA 91360, USA.
Miranda M HuttDepartment of Chemistry, Swenson Science Center, California Lutheran University, 60 West Olsen Rd. #3700, Thousand Oaks, CA 91360, USA.
California Lutheran University · US

Funding

National Science Foundation 1716986
6 · The paper itself

Abstract

The NIS synthetase family of enzymes responsible for the biosynthesis of siderophores is increasingly associated with bacterial virulence. Proteins in this class represent outstanding potential drug targets, assuming that basic biochemical and structural characterizations can be completed. Towards this goal, we have mated an improved synthesis of the non-commercial amino acid

Indexed as

Biological ProductsSiderophoresAmidesAmino AcidsCarbamatesEstersEthersHydroxamic AcidsLactamsLigasesSilica GelAmidesAmino AcidsBiological ProductsCarbamatesdesferrioxamine EEstersEthersHydroxamic AcidsLactamsLigasesSiderophoresSilica Gelantibacterialantibioticbacterial virulenceferric chelatorhydroxamatemacrocycleN-hydroxy-N-succinylcadaverine (HSC)NRPS-independent siderophore (NIS) synthesissiderophoretrihydroxamic acid

Identifiers

PMID36234688
PMCPMC9571020
OpenAlexW4296743347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.