Evidence map›Paper›PMID 36234686›Full record

ArticleMolecules (Basel, Switzerland)2022

Structure Activity Relationship Studies around

Dabbugoddu Brahmaiah, Anagani Kanaka Durga Bhavani, Pasula Aparna, Nangunoori Sampath Kumar, Hélène Solhi, Rémy Le Guevel, Blandine Baratte, Thomas Robert, Sandrine Ruchaud, Stéphane Bach and 6 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Research towards selective inhibition of the CLK3 kinase.Beilstein journal of organic chemistry · 2025
    Article
  2. Synthesis and cytotoxicity studies of novelBeilstein journal of organic chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Dabbugoddu BrahmaiahChemveda Life Sciences India Pvt. Ltd., #B-11/1, IDA Uppal, Hyderabad-500039, Telangana, India.
Anagani Kanaka Durga BhavaniDepartment of Chemistry, Osmania University, Hyderabad 500007, Telangana, India.
Pasula AparnaJawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500 085, Telangana, India.
Nangunoori Sampath KumarChemveda Life Sciences India Pvt. Ltd., #B-11/1, IDA Uppal, Hyderabad-500039, Telangana, India.
Hélène SolhiUniv Rennes, PlateformImPACcell, BIOSIT, F-35000 Rennes, France.
Rémy Le GuevelUniv Rennes, PlateformImPACcell, BIOSIT, F-35000 Rennes, France.
Blandine BaratteSorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.ORCID 0000-0002-2064-9558
Thomas RobertSorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.
Sandrine RuchaudSorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.ORCID 0000-0002-4606-6625
Stéphane BachSorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.ORCID 0000-0002-7186-7483
Surender Singh JadavCSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, TS, India.ORCID 0000-0002-5397-8956
Chada Raji ReddyCSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, TS, India.
Paul MossetUniv Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000 Rennes, France.
Nicolas GouaultUniv Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000 Rennes, France.
Nicolas LevoinBioprojet-Biotech, 4 rue du Chesnay Beauregard, BP 96205, 35762 Saint Grégoire, France.ORCID 0000-0002-7731-736X
René GréeUniv Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000 Rennes, France.
Centre National de la Recherche Scientifique · FRIndian Institute of Chemical Technology · INJawaharlal Nehru Technological University, Hyderabad · INStructure Fédérative de Recherche en Biologie et Santé de Rennes · FRBiotech (Brazil) · BROsmania University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three series of our lead CLK1 inhibitor

Indexed as

Protein Kinase InhibitorsHumansModels, MolecularMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipProtein Kinase InhibitorsCLK-kinasescytotoxicityDYRK1A kinasekinasesmolecular modellingquinazoline

Identifiers

PMID36234686
PMCPMC9571063
OpenAlexW4296741799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.