ArticleNanomaterials (Basel, Switzerland)2022
Low Toxicity of Metal-Organic Framework MOF-74(Co) Nano-Particles In Vitro and In Vivo.
Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Histopathological and biochemical profiling of Carfilzomib-loaded Fe-Co MOFs.Discover nano · 2025Article
- Harnessing curcumin in a multifunctional biodegradable metal-organic framework (bio-MOF) for targeted colorectal cancer theranostics.Drug delivery and translational research · 2025Article
- Intranasal delivery of metformin using metal-organic framework (MOF)-74-Mg nanocarriers.Advanced composites and hybrid materials · 2025Article
- Article
- Synthesis of a New Co Metal-Organic Framework Assembled from 5,10,15,20-Tetrakis((pyridin-4-yl) phenyl)porphyrin "Co-MTPhPyP" and Its Application to the Removal of Heavy Metal Ions.Molecules (Basel, Switzerland) · 2023Article
- Advances of Cobalt Nanomaterials as Anti-Infection Agents, Drug Carriers, and Immunomodulators for Potential Infectious Disease Treatment.Pharmaceutics · 2022Review
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7 authors.
Funding
Abstract
With the rapid development of metal-organic frameworks (MOF), the toxicity and environmental safety of MOF materials should be thoroughly investigated. The behaviors and bio-effects of MOF materials after oral exposure are largely unknown. In this study, we performed a pilot toxicity evaluation of MOF-74(Co) nanoparticles (NPs) both in vitro and in vivo. The cell viability and cell cycle were monitored after LO2 cells were incubated with MOF-74(Co). The Co contents, bodyweight, serum biochemistry, histopathological changes, and oxidative stress parameters were measured after oral exposure to MOF-74(Co) NPs in mice. LO2 cells showed viability loss at 100 mg/L. The cell cycle arrest was more sensitive, which was observed even at 12.5 mg/L. MOF-74(Co) NPs led to a significant accumulation of Co in the liver and kidneys. No bodyweight loss was observed and the serum biochemical index was mainly unchanged. Except for slight inflammation, the histopathological images of the liver and kidneys after oral exposure to MOF-74(Co) NPs were normal compared to the control. Meaningful oxidative stress was found in the liver and kidneys. The results collectively indicated the low toxicity of MOF-74(Co) NPs after oral exposure in mice.
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