ReviewJournal of clinical medicine2022
Neuromodulation Applied to Diseases: The Case of HRV Biofeedback.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The effects of heart rate variability biofeedback on functional gastrointestinal disorders: a scoping review.Frontiers in physiology · 2025Pooled it
- The Effects of a Single Vagus Nerve's Neurodynamics on Heart Rate Variability in Chronic Stress: A Randomized Controlled Trial.Sensors (Basel, Switzerland) · 2024Trial
- Article
- Short-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies.Particle and fibre toxicology · 2025Article
- The Predictive Value of Heart Rate Variability for the Prognosis of Patients with Mild to Moderate Traumatic Brain Injury.Neurology and therapy · 2025Article
- Breathwork for Chronic Stress and Mental Health: Does Choosing a Specific Technique Matter?Medical sciences (Basel, Switzerland) · 2025Review
- Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities.Molecular cancer · 2025Review
- Vagal Nerve Biofeedback Intervention for Improving Health Outcomes Among Ukrainian Forced Migrants: A Proof-of-Concept Study.International journal of environmental research and public health · 2025Article
- Evaluation of a New Mobile Virtual Reality Setup to Alter Pain Perception: Pilot Development and Usability Study in Healthy Participants.JMIR serious games · 2024Article
- Association of Sympathovagal Imbalance with Increased Inflammation and Impaired Adaptive Immunity in Bladder Cancer Patients.International journal of molecular sciences · 2024Article
- Preoperative vagal activity predicts clinical outcomes after total knee replacement.Experimental and therapeutic medicine · 2024Article
- Exploring Heart Rate Variability Biofeedback as a Nonpharmacological Intervention for Enhancing Perioperative Care: A Narrative Review.Turkish journal of anaesthesiology and reanimation · 2024Article
- State- and frequency-dependence in autonomic rebalance mediated by intradermal auricular electroacupuncture stimulation.Frontiers in neuroscience · 2024Article
- Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Pathological Heart Rate Regulation in Apparently Healthy Individuals.Entropy (Basel, Switzerland) · 2023Article
- Vagal Nerve Activity and Short-Term Clinical Outcomes after Stroke: What Is Left May Not Be Right.Journal of clinical medicine · 2023Article
- Neuroimaging Studies of the Neural Correlates of Heart Rate Variability: A Systematic Review.Journal of clinical medicine · 2023Review
- The effect and mechanisms of music therapy on the autonomic nervous system and brain networks of patients of minimal conscious states: a randomized controlled trial.Frontiers in neuroscience · 2023Article
- The promising prognostic value of vagal nerve activity at the initial management of ovarian cancer.Frontiers in oncology · 2022Article
- Harnessing non‑invasive vagal neuromodulation: HRV biofeedback and SSP for cardiovascular and autonomic regulation (Review).Medicine internationalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vagus or "wandering" nerve is the main branch of the parasympathetic nervous system (PNS), innervating most internal organs crucial for health. Activity of the vagus nerve can be non-invasively indexed by heart-rate variability parameters (HRV). Specific HRV parameters predict less all-cause mortality, lower risk of and better prognosis after myocardial infarctions, and better survival in cancer. A non-invasive manner for self-activating the vagus is achieved by performing a slow-paced breathing technique while receiving visual feedback of one's HRV, called HRV-biofeedback (HRV-B). This article narratively reviews the biological mechanisms underlying the role of vagal activity and vagally mediated HRV in hypertension, diabetes, coronary heart disease (CHD), cancer, pain, and dementia. After searching the literature for HRV-B intervention studies in each condition, we report the effects of HRV-B on clinical outcomes in these health conditions, while evaluating the methodological quality of these studies. Generally, the levels of evidence for the benefits of HRV-B is high in CHD, pain, and hypertension, moderate in cancer, and poor in diabetes and dementia. Limitations and future research directions are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.