ArticleJournal of clinical medicine2022
The Value of Hemoglobin Glycation Index-Diabetes Mellitus System in Evaluating and Predicting Incident Stroke in the Chinese Population.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hemoglobin glycation index and mortality risk in severe community-acquired pneumonia: a retrospective study.Journal of thoracic disease · 2026Article
- Association of hemoglobin glycation index with the severity and mortality of cardiovascular-kidney-metabolic syndrome: a population-based cohort study.Cardiovascular diabetology. Endocrinology reports · 2025Article
- The Association Between the Hemoglobin Glycation Index and Cardiometabolic Diseases: A Mini-Review.Journal of clinical hypertension (Greenwich, Conn.) · 2025Review
- The relationship between hemoglobin glycation index and all-cause mortality in ill critically patients with heart failure: a retrospective study in MIMIC-IV database.BMC cardiovascular disorders · 2025Article
- Association between hemoglobin glycation index and poor outcome after endovascular thrombectomy in acute ischemic stroke.Frontiers in aging neuroscience · 2025Article
- Risk and mediation analyses of hemoglobin glycation index and survival prognosis in patients with sepsis.Clinical and experimental medicine · 2024Article
- Association between hemoglobin glycation index and non-alcoholic fatty liver disease in the patients with type 2 diabetes mellitus.Journal of diabetes investigation · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
We aimed to clarify the effect of the hemoglobin glycation index (HGI)-diabetes mellitus (DM) system in evaluating the risk of incident stroke. We followed up on 2934 subjects in rural regions of Northeast China, established Cox proportional hazards models to evaluate the effects of the HGI-DM system in describing stroke risk, and further conducted a discrimination analysis to confirm the improvement in HGI based on the traditional stroke risk model. After a median of 4.23 years of follow-up, 79 subjects developed stroke or related death. DM-high HGI condition significantly elevated the risk of incident stroke (hazard ratio (HR): 2.655, 95% confidence interval (CI): 1.251-5.636). In addition, higher HGI levels elevated the risk of stroke, even if the patients did not have DM (HR: 1.701, 95% CI: 1.136-2.792), but DM failed to bring an extra risk of incident stroke to patients with lower HGI levels (HR: 1.138, 95% CI: 0.337-3.847). The discrimination analysis indicated that the integrated discrimination index (IDI) of the HGI model was 0.012 (95% CI: 0.007-0.015) and that the net reclassification index (NRI) was 0.036 (95% CI: 0.0198-0.0522). These results indicated HGI was associated with the onset of stroke, and high HGI indicated an aggravated trend in glycemic status and increased risk of incident stroke. The HGI-DM system enabled us to identify the different glucose statuses of patients, to conduct suitable treatment strategies, as well as to improve the predictability of incident stroke based on the traditional model.
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