Evidence map›Paper›PMID 36233645›Full record

ArticleJournal of clinical medicine2022

Transcriptomic Analysis of Conserved Telomere Maintenance Component 1 (CTC1) and Its Association with Leukemia.

Saadiya Zia, Netasha Khan, Komal Tehreem, Nazia Rehman, Rokayya Sami, Roua S Baty, Faris J Tayeb, Majed N Almashjary, Nouf H Alsubhi, Ghadeer I Alrefaei and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Saadiya ZiaDepartment of Biosciences, COMSATS University Islamabad (CUI), Islamabad 45550, Pakistan.ORCID 0000-0002-2265-0667
Netasha KhanDepartment of Biosciences, COMSATS University Islamabad (CUI), Islamabad 45550, Pakistan.
Komal TehreemDepartment of Biosciences, COMSATS University Islamabad (CUI), Islamabad 45550, Pakistan.ORCID 0000-0002-3608-0968
Nazia RehmanDepartment of Biosciences, COMSATS University Islamabad (CUI), Islamabad 45550, Pakistan.ORCID 0000-0002-3588-7014
Rokayya SamiDepartment of Food Science and Nutrition, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-3162-9453
Roua S BatyDepartment of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0001-5324-0014
Faris J TayebDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 47713, Saudi Arabia.ORCID 0000-0002-8906-198X
Majed N AlmashjaryDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 22254, Saudi Arabia.ORCID 0000-0002-6619-0287
Nouf H AlsubhiBiological Sciences Department, College of Science and Arts, King Abdulaziz University, Rabigh 21911, Saudi Arabia.ORCID 0000-0003-4450-0210
Ghadeer I AlrefaeiDepartment of Biology, College of Science, University of Jeddah, P.O. Box 80327, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-0615-5321
Ramla ShahidDepartment of Biosciences, COMSATS University Islamabad (CUI), Islamabad 45550, Pakistan.ORCID 0000-0001-7707-6431
COMSATS University Islamabad · PKKing Abdulaziz University · SATaif University · SAUniversity of Jeddah · SAUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomere length (TEL) regulation is important for genome stability and is governed by the coordinated role of shelterin proteins, telomerase (TERT), and CST (CTC1/OBFC1/TEN1) complex. Previous studies have shown the association of telomerase expression with the risk of acute lymphoblastic leukemia (ALL). However, no data are available for CST association with the ALL. The current pilot study was designed to evaluate the CST expression levels in ALL. In total, 350 subjects were recruited, including 250 ALL cases and 100 controls. The subjects were stratified by age and categorized into pediatrics (1-18 years) and adults (19-54 years). TEL and expression patterns of CTC1, OBFC1, and TERT genes were determined by qPCR. The univariable logistic regression analysis was performed to determine the association of gene expression with ALL, and the results were adjusted for age and sex in multivariable analyses. Pediatric and adult cases did not reflect any change in telomere lengths relative to controls. However, expression of CTC1, OBFC1, and TERT genes were induced among ALL cases. Multivariable logistic regression analyses showed association of CTC1 with ALL in pediatric [β estimate (standard error (SE)= -0.013 (0.007),

Indexed as

acute lymphoblastic leukemiarisk biomarkertelomere lengthtelomere modulating genes

Identifiers

PMID36233645
PMCPMC9571731
OpenAlexW4297982181

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.