Evidence map›Paper›PMID 36233621›Full record

ReviewJournal of clinical medicine2022

Strategies to Overcome HLA Sensitization and Improve Access to Retransplantation after Kidney Graft Loss.

Rita Leal, Clara Pardinhas, António Martinho, Helena Oliveira Sá, Arnaldo Figueiredo, Rui Alves

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Racial and immunologic disparities impact access to kidney rewaitlisting and retransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Resolving ScRNA-Seq Signatures of Antigen-Specific CD4bioRxiv : the preprint server for biology · 2025
    Article
  8. Adult outcomes of childhood kidney replacement therapy in Europe from 2008 to 2019: an ERA Registry study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rita LealNephrology Department, Centro Hospitalar e Universitário de Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-0614-3902
Clara PardinhasNephrology Department, Centro Hospitalar e Universitário de Coimbra, 3000-548 Coimbra, Portugal.
António MartinhoCoimbra Histocompatibility Center, Portuguese Institute of Blood and Transplantation, 3041-861 Coimbra, Portugal.
Helena Oliveira SáNephrology Department, Centro Hospitalar e Universitário de Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0001-5231-2629
Arnaldo FigueiredoFaculty of Medicine, University of Coimbra, 3004-531 Coimbra, Portugal.
Rui AlvesNephrology Department, Centro Hospitalar e Universitário de Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-3922-3618
Hospitais da Universidade de Coimbra · PTInstituto Português de Oncologia de Coimbra Francisco Gentil · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of patients waitlisted for kidney transplantation have a previously failed graft. Retransplantation provides a significant improvement in morbidity, mortality, and quality of life when compared to dialysis. However, HLA sensitization is a major barrier to kidney retransplantation and the majority of the highly sensitized patients are waiting for a subsequent kidney transplant. A multidisciplinary team that includes immunogeneticists, transplant nephrologists and surgeons, and adequate allocation policies is fundamental to increase access to a kidney retransplant. A review of Pubmed, ScienceDirect, and the Cochrane Library was performed on the challenges of kidney retransplantation after graft loss, focusing on the HLA barrier and new strategies to overcome sensitization. Conclusion: Technical advances in immunogenetics, new desensitization protocols, and complex allocation programs have emerged in recent years to provide a new hope to kidney recipients with a previously failed graft.

Indexed as

allocationallossensitizationimmunosuppressionkidney graft failurekidney retransplantation

Identifiers

PMID36233621
PMCPMC9572793
OpenAlexW4297477287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.