ReviewJournal of clinical medicine2022
Respiratory Subsets in Patients with Moderate to Severe Acute Respiratory Distress Syndrome for Early Prediction of Death.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 15 citations in OpenAlex.
- Heterogenous treatment effect of neuromuscular blocking agents for moderate-to-severe ARDS: a post hoc Markov model re-analysis of the ACURASYS trial.Intensive care medicine · 2025Trial
- Comment on "Esketamine versus dexmedetomidine fora oxygenation and postoperative quality of recovery in thoracoscopic surgery: a randomized, double‑blind, non-inferiority controlled trial" by Feng et al.Journal of anesthesia · 2026Article
- Beyond injury severity: monocyte-associated small extracellular vesicles distinguish respiratory-support trajectories following thoracic trauma.BMC pulmonary medicine · 2026Article
- Acute hypoxemic respiratory failure: from static severity to trajectory-based phenotyping.Intensive care medicine · 2026Article
- Invasive ventilation and association with outcomes in heart failure-related cardiogenic shock.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Construction and validation of a prognostic prediction model for critically ill lung cancer patients based on respiratory functional reserve and systemic inflammatory characteristics.American journal of cancer research · 2026Article
- Machine Learning Techniques for the Analysis of the Influence of Blood Gasometry Parameters on Acid-Base Homeostasis in Pediatric Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Predicting Outcome and Duration of Mechanical Ventilation in Acute Hypoxemic Respiratory Failure: The PREMIER Study.Journal of clinical medicine · 2025Article
- ARDS Subphenotypes as a Guide to Therapy and Enrollment into Therapeutic Trials: Not So Fast.Journal of clinical medicine · 2025Article
- Early Prediction of ICU Mortality in Patients with Acute Hypoxemic Respiratory Failure Using Machine Learning: The MEMORIAL Study.Journal of clinical medicine · 2025Article
- Stroke-associated pneumonia with low PaOFrontiers in neurology · 2025Article
- The efficacy and safety of combined therapy with endobronchial tamponade and bronchial artery embolization for massive hemoptysis.BMC pulmonary medicine · 2024Article
- Predicting the Length of Mechanical Ventilation in Acute Respiratory Disease Syndrome Using Machine Learning: The PIONEER Study.Journal of clinical medicine · 2024Article
- When are pulmonologists consulted? Trends and outcomes of pulmonary consultations for unspecified hypoxia.Proceedings (Baylor University. Medical Center) · 2024Article
- Association between (ΔPaO2/FiO2)/PEEP and in-hospital mortality in patients with COVID-19 pneumonia: A secondary analysis.PloS one · 2024Article
- Post-operative sepsis-induced acute respiratory distress syndrome: risk factors for a life-threatening complication.Frontiers in medicine · 2024Article
- Redefining ARDS: a paradigm shift.Critical care (London, England) · 2023Review
Corrections and comments
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Authors and funding
29 authors at 20 institutions in 4 countries.
Funding
Abstract
Introduction: In patients with acute respiratory distress syndrome (ARDS), the PaO2/FiO2 ratio at the time of ARDS diagnosis is weakly associated with mortality. We hypothesized that setting a PaO2/FiO2 threshold in 150 mm Hg at 24 h from moderate/severe ARDS diagnosis would improve predictions of death in the intensive care unit (ICU). Methods: We conducted an ancillary study in 1303 patients with moderate to severe ARDS managed with lung-protective ventilation enrolled consecutively in four prospective multicenter cohorts in a network of ICUs. The first three cohorts were pooled (n = 1000) as a testing cohort; the fourth cohort (n = 303) served as a confirmatory cohort. Based on the thresholds for PaO2/FiO2 (150 mm Hg) and positive end-expiratory pressure (PEEP) (10 cm H2O), the patients were classified into four possible subsets at baseline and at 24 h using a standardized PEEP-FiO2 approach: (I) PaO2/FiO2 ≥ 150 at PEEP < 10, (II) PaO2/FiO2 ≥ 150 at PEEP ≥ 10, (III) PaO2/FiO2 < 150 at PEEP < 10, and (IV) PaO2/FiO2 < 150 at PEEP ≥ 10. Primary outcome was death in the ICU. Results: ICU mortalities were similar in the testing and confirmatory cohorts (375/1000, 37.5% vs. 112/303, 37.0%, respectively). At baseline, most patients from the testing cohort (n = 792/1000, 79.2%) had a PaO2/FiO2 < 150, with similar mortality among the four subsets (p = 0.23). When assessed at 24 h, ICU mortality increased with an advance in the subset: 17.9%, 22.8%, 40.0%, and 49.3% (p < 0.0001). The findings were replicated in the confirmatory cohort (p < 0.0001). However, independent of the PEEP levels, patients with PaO2/FiO2 < 150 at 24 h followed a distinct 30-day ICU survival compared with patients with PaO2/FiO2 ≥ 150 (hazard ratio 2.8, 95% CI 2.2−3.5, p < 0.0001). Conclusions: Subsets based on PaO2/FiO2 thresholds of 150 mm Hg assessed after 24 h of moderate/severe ARDS diagnosis are clinically relevant for establishing prognosis, and are helpful for selecting adjunctive therapies for hypoxemia and for enrolling patients into therapeutic trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.