ArticleJournal of clinical medicine2022
Current Challenges in the Treatment of the Omphalocele-Experience of a Tertiary Center from Romania.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Congenital Gastrointestinal Malformations in a Romanian Tertiary Centre (2020-2024): A Retrospective Cohort Study of Diagnosis, Distribution, and Outcomes.Diagnostics (Basel, Switzerland) · 2026Article
- Proxy-reported health-related quality of life in children with omphalocele: a cross-sectional study in China.Translational pediatrics · 2026Article
- Omphalocele and Associated Anomalies: Exploring Pulmonary Development and Genetic Correlations-A Literature Review.Diagnostics (Basel, Switzerland) · 2025Review
- Nosocomial Infections Affecting Newborns with Abdominal Wall Defects.Healthcare (Basel, Switzerland) · 2023Article
- Omphalocele and Cardiac Abnormalities-The Importance of the Association.Diagnostics (Basel, Switzerland) · 2023Review
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10 authors.
Funding
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Abstract
Omphalocele is a congenital abdominal wall defect with a constant incidence in recent decades, sometimes representing a real burden for neonatal intensive care units due to prolonged hospitalization and the evolution to death. In our study, we aimed to detect the main risk factors of an unfavorable evolution in the case of omphalocele.
methodsRetrospective cohort study of all neonates with omphalocele treated in our tertiary pediatric hospital during the last three decades; from 158 patients, 139 patients were eligible for the study. We tried to determine the risk of death using logistic regression model.
resultsIf the neonate develops sepsis, then there is an increased risk (13.03 times) of evolution to death. Similarly, the risk of death is 10.82 times higher in the case of developing acute renal failure, 6.28 times higher in the case of associated abnormalities, 5.54 in the case of developing hemorrhagic disease, and 3.78 in the case of conservative treatment (applied for giant omphalocele or severe chromosomal abnormalities). Prematurity increases by 3.62 times the risk of death. All six independent variables contributed 61.0% to the risk of death. The area under the ROC curve is 0.91, meaning that the diagnostic accuracy of our logistic regression model is very good for predicting the contribution of the six independent variables to the risk of death.
conclusionAlthough in the past 30 years we witnessed several improvements in the antenatal diagnosis and management of omphalocele, survival rate remained constant, 47.5% overall. Much effort is still needed to eliminate the risk factors for death in this condition.
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