Evidence map›Paper›PMID 36233573›Full record

ArticleJournal of clinical medicine2022

The Allergic Phenotype of Children and Adolescents with Selective IgA Deficiency: A Longitudinal Monocentric Study.

Bianca Laura Cinicola, Giulia Brindisi, Martina Capponi, Alessandra Gori, Lorenzo Loffredo, Giovanna De Castro, Caterina Anania, Alberto Spalice, Cristiana Alessia Guido, Cinzia Milito and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Bianca Laura CinicolaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-1268-5038
Giulia BrindisiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-5059-6082
Martina CapponiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Alessandra GoriDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Lorenzo LoffredoDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-6542-6235
Giovanna De CastroDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Caterina AnaniaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Alberto SpaliceDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Cristiana Alessia GuidoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Cinzia MilitoDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-2581-9250
Marzia DuseDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-9958-2570
Isabella QuintiDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-3328-7584
Federica PulvirentiDepartment of Internal Medicine and Infectious Diseases, Regional Reference Centre for Primary Immune Deficiencies, Azienda Ospedaliera Universitaria Policlinico Umberto I, 00161 Rome, Italy.
Anna Maria ZicariDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Sapienza University of Rome · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSelective IgA deficiency (SIgAD) is the most common inborn error of immunity. The exact prevalence and pathogenesis of allergy in SIgAD have not yet been defined. We aimed to describe the prevalence and the characteristics of allergy in pediatric SIgAD subjects, evaluate the association between allergy and other comorbidities, and define the immune phenotype of allergic and non-allergic patients.

methodsClinical and immunological data from 67 SIgAD patients were collected over a 13-year period at a single center. Patients' characteristics were analyzed according to the presence of allergy.

resultsAllergy was diagnosed in 34% of SIgAD patients, with a median age at allergy diagnosis of 8 years. Allergy was the second-most-common clinical manifestation, following recurrent respiratory infections. Among the allergic group, 74% had rhinitis, 30% asthma, 30% atopic dermatitis, and 22% food allergy; one out of three had more than one allergic manifestation. SIgAD patients showed more frequent transitory lymphopenia and a lower count of CD19+ at diagnosis than at last FU. However, compared to non-allergic subjects, allergic patients did not differ in their immune phenotype, number and severity of infections, or increased autoimmunity.

conclusionsIn our longitudinal study, compared to non-allergic SIgAD patients, those with allergies did not present a more severe immune defect or complex clinical phenotype. However, evaluation and early identification of allergy in the context of SIgAD assessment, both at diagnosis and during FU, and definition of a proper management are important to prevent complications and improve the patient's quality of life.

Indexed as

allergyasthmaautoimmunityinborn errors of immunityinfectionsprimary immunodeficiencySIgAD

Identifiers

PMID36233573
PMCPMC9573591
OpenAlexW4297540783

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.