ReviewJournal of clinical medicine2022
The Emerging Clinical Significance of the Red Cell Distribution Width as a Biomarker in Chronic Obstructive Pulmonary Disease: A Systematic Review.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Prognostic value of combined RDW, NLR, PLR, and mpv detection in patients with acute exacerbation of chronic obstructive pulmonary disease: a single-center retrospective cohort study.BMC pulmonary medicine · 2026Article
- Red Cell Distribution Width Predicts Mortality in Critically Ill Patients with COPD and Atrial Fibrillation: A Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Correlation between anemia-related red blood cell parameters and pulmonary function severity in patients with AECOPD.Frontiers in medicine · 2026Article
- The Predictive Value of Hemoglobin-to-Red Blood Cell Distribution Width Ratio for the Prognosis of Patients with Aortic Dissection: Based on the Medical Information Mart for Intensive Care-IV Database.Anatolian journal of cardiology · 2025Article
- Red Cell Distribution Width (RDW), Platelets and Platelet Index MPV/PLT Ratio as Specific Time Point Predictive Variables of Survival Outcomes in COVID-19 Hospitalized Patients.Journal of clinical medicine · 2025Article
- Red cell distribution width to albumin ratio (RAR) as a prognostic marker for mortality in critical care patients: a large-scale retrospective cohort study.European journal of medical research · 2025Article
- Clinical significance of HIF-1α, ET-1, and NO as biomarkers in chronic obstructive pulmonary disease patients with pulmonary hypertension.Biomolecules & biomedicine · 2025Article
- Association of red cell distribution width/albumin ratio and 28-day mortality in chronic obstructive pulmonary disease patients with atrial fibrillation: a medical information mart for intensive care IV study.BMC cardiovascular disorders · 2025Article
- Unveiling the Prognostic Power of HRR in ICU-Admitted COPD Patients: A MIMIC-IV Database Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Predictive role of red blood cell distribution width and hemoglobin-to-red blood cell distribution width ratio for mortality in patients with COPD: evidence from NHANES 1999-2018.BMC pulmonary medicine · 2024Article
- A Systematic Review and Meta-Analysis of Mean Platelet Volume and Platelet Distribution Width in Patients with Obstructive Sleep Apnoea Syndrome.Biomedicines · 2024Review
- A predictive model for frequent exacerbator phenotype of acute exacerbations of chronic obstructive pulmonary disease.Journal of thoracic disease · 2023Article
- The association between red cell distribution width and newly diagnosed hypertension among adults in Northern Sudan: a case-control study.The Libyan journal of medicine · 2023Article
- Red Cell Distribution Width and Prediabetes in Adults in Northern Sudan: A Case-Control Study.Hematology reports · 2023Article
- Development and Validation of a Predictive Model Based on LASSO Regression: Predicting the Risk of Early Recurrence of Atrial Fibrillation after Radiofrequency Catheter Ablation.Diagnostics (Basel, Switzerland) · 2023Article
- Exploring Mechanisms in COPD: Time for Biomarker Reappraisal?Journal of clinical medicine · 2023Article
- Serum YKL-40 Levels, Leukocyte Profiles, and Acute Exacerbations of Advanced COPD.Journal of clinical medicine · 2023Article
- Early detection and prediction of acute exacerbation of chronic obstructive pulmonary disease.Chinese medical journal pulmonary and critical care medicine · 2023Review
- Association between Red Blood Cell Distribution Width and Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Hypercapnia is associated with an increased risk of ICU admission and reduced inflammatory responses in AECOPD patients with severe pneumonia.Therapeutic advances in respiratory diseaseObservational
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an intense focus on the identification of novel biomarkers of chronic obstructive pulmonary disease (COPD) to enhance clinical decisions in patients with stable disease and acute exacerbations (AECOPD). Though several local (airway) and circulatory inflammatory biomarkers have been proposed, emerging evidence also suggests a potential role for routine haematological parameters, e.g., the red cell distribution width (RDW). We conducted a systematic literature search in PubMed, Web of Science, and Scopus, from inception to April 2022, for articles investigating the diagnostic and prognostic role of the RDW in stable COPD and AECOPD. The risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Significant associations between the RDW and the presence and severity of disease, outcomes (mortality, hospital readmission), and other relevant clinical parameters (right heart failure, pulmonary arterial hypertension) were reported in 13 out of 16 studies in stable COPD (low risk of bias in 11 studies), and 17 out of 21 studies of AECOPD (low risk of bias in 11 studies). Pending further research, our systematic review suggests that the RDW might be useful, singly or in combination with other parameters, for the diagnosis and risk stratification of patients with stable COPD and AECOPD (PROSPERO registration number: CRD42022348304).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.