Evidence map›Paper›PMID 36233347›Full record

ArticleInternational journal of molecular sciences2022

Methionine γ-Lyase-Daidzein in Combination with S-Propyl-L-cysteine Sulfoxide as a Targeted Prodrug Enzyme System for Malignant Solid Tumor Xenografts.

Louay Abo Qoura, Elena Morozova, Vitalia Kulikova, Saida Karshieva, Darina Sokolova, Vasiliy Koval, Svetlana Revtovich, Tatyana Demidkina, Vadim S Pokrovsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. New Anticancer Agents: Design, Synthesis and Evaluation.International journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Louay Abo QouraDepartment of Biochemistry, RUDN University, 117198 Moscow, Russia.
Elena MorozovaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Vitalia KulikovaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Saida KarshievaLaboratory of Combined Treatment, N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health of Russian Federation, 115478 Moscow, Russia.
Darina SokolovaDepartment of Biochemistry, RUDN University, 117198 Moscow, Russia.ORCID 0000-0003-3972-2425
Vasiliy KovalEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Svetlana RevtovichEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Tatyana DemidkinaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Vadim S PokrovskyDepartment of Biochemistry, RUDN University, 117198 Moscow, Russia.ORCID 0000-0003-4006-9320
Engelhardt Institute of Molecular Biology · RUPeoples' Friendship University of Russia · RUMinistry of Health of the Russian Federation · RU

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2021-1060Russian Science Foundation 20-14-00258Russian Science Foundation 21-75-30020
6 · The paper itself

Abstract

The purpose of this study was to determine the anticancer effect of dipropyl thiosulfinate produced in situ by the pharmacological pair: (1) conjugated with daidzein C115H methionine γ-lyase (EC 4.4.1.11, C115H MGL-Dz) and (2) the substrate, S-propyl-L-cysteine sulfoxide (propiin) against various solid tumor types in vitro and in vivo. The MTT test was used to calculate IC

Indexed as

Colonic NeoplasmsPancreatic NeoplasmsProdrugsProstatic NeoplasmsAnimalsCarbon-Sulfur LyasesCell Line, TumorCysteineHeterograftsHumansIsoflavonesMaleMethionineMiceMice, NudeSulfoxidesCarbon-Sulfur LyasesCysteinedaidzeinIsoflavonesL-methionine gamma-lyaseMethionineProdrugsS-propyl cysteine sulfoxideSulfoxidesanticancer activitydaidzeindirected enzyme prodrug therapymethionine γ-lyasethiosulfinates

Identifiers

PMID36233347
PMCPMC9569779
OpenAlexW4304136348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.