Evidence map›Paper›PMID 36233331›Full record

ArticleInternational journal of molecular sciences2022

Enhanced Bioactivity of Tailor-Made Glycolipid Enriched Manuka Honey.

André Delavault, Ahmed E Zoheir, Delphine Muller, Rebecca Hollenbach, Kersten S Rabe, Katrin Ochsenreither, Jens Rudat, Christoph Syldatk

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

André DelavaultTechnical Biology, Institute of Process Engineering in Life Sciences II, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0002-2232-1580
Ahmed E ZoheirDepartment of Genetics and Cytology, National Research Center (NRC), Cairo 12622, Egypt.ORCID 0000-0001-5656-2932
Delphine MullerTechnical Biology, Institute of Process Engineering in Life Sciences II, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
Rebecca HollenbachTechnical Biology, Institute of Process Engineering in Life Sciences II, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0001-5387-4148
Kersten S RabeMolecular Evolution, Institute for Biological Interfaces 1 (IBG-1), Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany.ORCID 0000-0001-7909-8191
Katrin OchsenreitherTechnical Biology, Institute of Process Engineering in Life Sciences II, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0002-5797-2789
Jens RudatTechnical Biology, Institute of Process Engineering in Life Sciences II, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0003-4997-8459
Christoph SyldatkTechnical Biology, Institute of Process Engineering in Life Sciences II, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
Karlsruhe Institute of Technology · DE

Funding

Federal Ministry of Education and Research Allianz Biotenside AZ: 031B0469C
6 · The paper itself

Abstract

Glycolipids can be synthetized in deep eutectic solvents (DESs) as they possess low water content allowing a reversed lipase activity and thus enables ester formation. Based on this principle, honey can also serve as a media for glycolipid synthesis. Indeed, this supersaturated sugar solution is comparable in terms of physicochemical properties to the sugar-based DESs. Honey-based products being commercially available for therapeutic applications, it appears interesting to enhance its bioactivity. In the current work, we investigate if enriching medical grade honey with in situ enzymatically-synthetized glycolipids can improve the antimicrobial property of the mixture. The tested mixtures are composed of Manuka honey that is enriched with octanoate, decanoate, laurate, and myristate sugar esters, respectively dubbed GOH, GDH, GLH, and GMH. To characterize the bioactivity of those mixtures, first a qualitative screening using an agar well diffusion assay has been performed with methicillin-resistant

Indexed as

Anti-Infective AgentsHoneyMethicillin-Resistant Staphylococcus aureusAgarAnti-Bacterial AgentsCaprylatesDecanoatesEscherichia coliEstersGlycolipidsLauratesLipaseMicrobial Sensitivity TestsMyristatesSugarsWaterAgarAnti-Bacterial AgentsAnti-Infective AgentsCaprylatesDecanoatesEstersGlycolipidsLauratesLipaseMyristatesSugarsWaterantimicrobialdeep eutectic solventesterificationglycolipid synthesislipaseManuka honeystress biosensing

Identifiers

PMID36233331
PMCPMC9570014
OpenAlexW4304136193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.