ReviewInternational journal of molecular sciences2022
Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Apolipoprotein E2/2 (APOE2/2) Genotype Is Associated With Reduced Choroidal Thickness.Investigative ophthalmology & visual science · 2026Article
- Spatial Selective Choroidal Stromal and Vascular Changes in Intermediate AMD: Insights From High-Density Optical Coherence Tomography Analysis.Investigative ophthalmology & visual science · 2026Article
- Geographic atrophy in age-related macular degeneration: phenotypic characterisation for clinical trial consideration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Correlation of drusen burden and vascular integrity in age-related macular degeneration using three-dimensional choroidal vascular model.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Non-exudative OCT findings in neovascular AMD.Eye (London, England) · 2025Review
- Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration.International journal of ophthalmology · 2025Article
- Age-Related Choroidal Involution Is Associated with the Senescence of Endothelial Progenitor Cells in the Choroid.Biomedicines · 2024Article
- Age related grid-wise spatial analysis of choroidal parameters in well characterised healthy population.Scientific reports · 2024Article
- LeptoVitelliform Maculopathy: delineating a distinct clinical entity from acquired vitelliform lesions.Eye (London, England) · 2024Observational
- Melanopsin in the human and chicken choroid.Experimental eye research · 2024Article
- Choroidal vascularity features of fundus tessellation in adults with high myopia.BMC ophthalmology · 2024Article
- Aging in Ocular Blood Vessels: Molecular Insights and the Role of Oxidative Stress.Biomedicines · 2024Review
- The role of the retinal vasculature in age-related macular degeneration: a spotlight on OCTA.Eye (London, England) · 2024Review
- The Choroidal Vascularity Index Versus Optical Coherence Tomography Angiography in the Evaluation of the Choroid with a Focus on Age-Related Macular Degeneration.Tomography (Ann Arbor, Mich.) · 2023Review
- The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy.International journal of molecular sciences · 2023Review
- Yellow Subthreshold Micropulse Laser in Retinal Diseases: An In-Depth Analysis and Review of the Literature.Ophthalmology and therapy · 2023Review
- Prognostic Optical Coherence Tomography Biomarkers in Neovascular Age-Related Macular Degeneration.Journal of clinical medicine · 2023Review
- Short-term postoperative changes in the choroidal vascularity index in patients with a unilateral epiretinal membrane.BMC ophthalmology · 2023Article
- Long-term effects of combined brilliant blue G and xenon light induced retinal toxicity following macular hole repair surgery.BMC ophthalmology · 2023Article
- From stress to sight: The role of mechanical forces in the retinal diseases.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring with aging and AMD with a brief overview of the principal multimodal imaging modalities and techniques that enable the optimal in vivo visualization of choroidal modifications. The molecular aspects that target the choroid in AMD mainly involve human leukocyte antigen (HLA) expression, complement dysregulation, leukocyte interaction at Bruch's membrane, and mast cell infiltration of the choroid. A mechanistic link between high-risk genetic loci for AMD and mast cell recruitment has also been recently demonstrated. Recent advances in multimodal imaging allow more detailed visualization of choroidal structure, identifying alterations that may expand our comprehension of aging and AMD development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.