Evidence map›Paper›PMID 36233238›Full record

SynthesisInternational journal of molecular sciences2022

The Role of Virulence Factors in Neonatal Sepsis Caused by Enterobacterales: A Systematic Review.

Lucia Barcellini, Giulia Ricci, Ilia Bresesti, Aurora Piazza, Francesco Comandatore, Mike Sharland, Gian Vincenzo Zuccotti, Laura Folgori

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. A Rare Intruder: Neonatal Meningoencephalitis byAntibiotics (Basel, Switzerland) · 2026
    Review
  4. Advancing Understanding ofMicroorganisms · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Lucia BarcelliniDepartment of Paediatrics, Children Hospital V. Buzzi, University of Milan, 20154 Milan, Italy.
Giulia RicciDepartment of Paediatrics, Children Hospital V. Buzzi, University of Milan, 20154 Milan, Italy.ORCID 0000-0002-0225-9388
Ilia BresestiDivision of Neonatology, "F. Del Ponte" Hospital, Woman and Child Department, University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-6812-7556
Aurora PiazzaUnit of Microbiology and Clinical Microbiology, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Francesco ComandatoreDepartment of Biomedical and Clinical Sciences, Romeo and Enrica Invernizzi Pediatric Clinical Research Center, University of Milan, 20100 Milan, Italy.
Mike SharlandCentre for Neonatal and Paediatric Infection, Institute for Infection and Immunity, St. George's University of London, London SW17 9PE, UK.
Gian Vincenzo ZuccottiDepartment of Paediatrics, Children Hospital V. Buzzi, University of Milan, 20154 Milan, Italy.ORCID 0000-0002-2795-9874
Laura FolgoriDepartment of Paediatrics, Children Hospital V. Buzzi, University of Milan, 20154 Milan, Italy.
University of Milan · ITSt George's, University of London · GBUniversity of Insubria · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal sepsis is a life-threatening condition with high mortality. Virulence determinants relevant in causing Gram-negative (GN) neonatal sepsis are still poorly characterized. A better understanding of virulence factors (VFs) associated with GN neonatal sepsis could offer new targets for therapeutic interventions. The aim of this review was to assess the role of GN VFs in neonatal sepsis. We primarily aimed to investigate the main VFs leading to adverse outcome and second to evaluate VFs associated with increased invasiveness/pathogenicity in neonates. MEDLINE, Embase, and Cochrane Library were systematically searched for studies reporting data on the role of virulome/VFs in bloodstream infections caused by

Indexed as

BacteremiaGammaproteobacteriaGram-Negative Bacterial InfectionsNeonatal SepsisSepsisAnti-Bacterial AgentsHumansInfantInfant, NewbornVirulence FactorsAnti-Bacterial AgentsVirulence FactorsEnterobacteralesmortalityneonatal sepsisvirulence factorsvirulome

Identifiers

PMID36233238
PMCPMC9569801
OpenAlexW4303709799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.