Evidence map›Paper›PMID 36233185›Full record

ArticleInternational journal of molecular sciences2022

LPCAT4 Knockdown Alters Barrier Integrity and Cellular Bioenergetics in Human Urothelium.

Andrew S Mason, Claire L Varley, Olivia M Foody, Xiang Li, Katie Skinner, Dawn Walker, Tony R Larson, Daisuke Wakamatsu, Simon C Baker, Jennifer Southgate

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Andrew S MasonJack Birch Unit for Molecular Carcinogenesis, Department of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, UK.ORCID 0000-0002-8222-3974
Claire L VarleyJack Birch Unit for Molecular Carcinogenesis, Department of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, UK.
Olivia M FoodyJack Birch Unit for Molecular Carcinogenesis, Department of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, UK.
Xiang LiDepartment of Computer Science, University of Sheffield, Regent Court, 211 Portobello, Sheffield S1 4DP, UK.
Katie SkinnerJack Birch Unit for Molecular Carcinogenesis, Department of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, UK.ORCID 0000-0003-2113-0464
Dawn WalkerDepartment of Computer Science, University of Sheffield, Regent Court, 211 Portobello, Sheffield S1 4DP, UK.ORCID 0000-0001-8801-8093
Tony R LarsonMetabolomics and Proteomics Laboratory, Bioscience Technology Facility, The Department of Biology, The University of York, Heslington, York YO10 5DD, UK.ORCID 0000-0003-1337-3482
Daisuke WakamatsuPharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Simon C BakerJack Birch Unit for Molecular Carcinogenesis, Department of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, UK.ORCID 0000-0002-2755-6012
Jennifer SouthgateJack Birch Unit for Molecular Carcinogenesis, Department of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, UK.ORCID 0000-0002-0135-480X
University of York · GBUniversity of Sheffield · GB

Funding

ONO Pharmaceuticals Co. Ltd. (Osaka, Japan) NA
6 · The paper itself

Abstract

Urothelium is a transitional, stratified epithelium that lines the lower urinary tract, providing a tight barrier to urine whilst retaining the capacity to stretch and rapidly resolve damage. The role of glycerophospholipids in urothelial barrier function is largely unknown, despite their importance in membrane structural integrity, protein complex assembly, and the master regulatory role of PPARγ in urothelial differentiation. We performed lipidomic and transcriptomic characterisation of urothelial differentiation, revealing a metabolic switch signature from fatty acid synthesis to lipid remodelling, including 5-fold upregulation of

Indexed as

1-Acylglycerophosphocholine O-AcyltransferasePPAR gammaUrotheliumAdenosine TriphosphateCell DifferentiationEnergy MetabolismFatty AcidsGlycerophospholipidsHumansLipidsReceptors, GABA1-Acylglycerophosphocholine O-AcyltransferaseAdenosine TriphosphateFatty AcidsGlycerophospholipidsLipidsLPCAT4 protein, humanPPAR gammaReceptors, GABATSPO protein, humanAGPAT7glycerophospholipidslipidomicsLPEAT2LPLAT10phosphatidylcholinetranscriptomicstransepithelial electrical resistanceurotheliumwound healing

Identifiers

PMID36233185
PMCPMC9570021
OpenAlexW4303709848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.