Evidence map›Paper›PMID 36233147›Full record

ArticleInternational journal of molecular sciences2022

25-Hydroxyvitamin D Serum Levels Linked to Single Nucleotide Polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in Skeletal Muscle Aging in Institutionalized Elderly Men Not Supplemented with Vitamin D.

Diego Fernández-Lázaro, Juan Luis García Hernández, Eva Lumbreras, Juan Mielgo-Ayuso, Jesús Seco-Calvo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Diego Fernández-LázaroDepartment of Cellular Biology, Genetics, Histology and Pharmacology, Faculty of Health Sciences, Campus of Soria, University of Valladolid, 42003 Soria, Spain.ORCID 0000-0002-6522-8896
Juan Luis García HernándezMolecular Mechanisms of Cancer Program, Institute of Molecular and Cellular Biology of Cancer, Spanish National Research Council (CSIC), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-2146-5726
Eva LumbrerasInstitute of Biomedical Research of Salamanca (IBSAL), Cytogenetics-Molecular Genetics in Onco-Hematology, Cancer Research Center-University of Salamanca (IBMCC, USAL-CSIC), 37008 Salamanca, Spain.
Juan Mielgo-AyusoDepartment of Health Sciences, Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain.
Jesús Seco-CalvoPhysiotherapy Department, Institute of Biomedicine (IBIOMED), Campus of Vegazana, University of Leon, 24071 Leon, Spain.ORCID 0000-0002-7818-9777
Consejo Superior de Investigaciones Científicas · ESUniversidad de Burgos · ESUniversidad de Salamanca · ESUniversidad de Valladolid · ESUniversity of the Basque Country · ES

Funding

Chair of Knowledge and Innovation "Caja Rural de Soria" University of Valladolid Campus de Soria (Spain) SO-1-2020
6 · The paper itself

Abstract

Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging that results in an involution of muscle function and strength. Vitamin D deficiency is a common health problem worldwide, especially among the elderly, and hypovitaminosis D leads to musculoskeletal disorders. The aim of this study was to evaluate the impact and presence of a possible linkage between Single Nucleotide Polymorphisms (SNPs) CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs2228570), serum 25-OH/D concentrations and the link with the degree of sarcopenia in 19 institutionalized elderly men not supplemented with vitamin D. Levels of 25-OH vitamin D were quantified with a commercial enzyme-linked immunosorbent assay kit and 3 SNPs were genotyped with KASPar assays. Significant differences in 25-OH/D concentration were determined between the bi-allelic combinations of rs228679 and rs228570. We detected statistically significant weak positive correlations between the AA (rs10741657 and rs228570) and TT (rs228679) and alleles and 25-OH/D and the probability of having higher 25-OH/D concentrations was 2- to 3-fold higher. However, the GG alleles of the 3 SNPs showed that the probability of having optimal 25-0H/D concentrations decreases by 32% for rs10741657, 38% for rs228679, and 74% for rs228570, showing a strong negative correlation between the degree of sarcopenia and 25-OH/D levels. Allelic variations in CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs10741657) affect vitamin D levels and decisively influence the degree of sarcopenia in institutionalized elderly people.

Indexed as

Cholestanetriol 26-MonooxygenaseCytochrome P450 Family 2Receptors, CalcitriolSarcopeniaVitamin D-Binding ProteinVitamin D DeficiencyAgedAgingCalcifediolGenotypeHumansMaleMuscle, SkeletalPolymorphism, Single NucleotideVitamin DVitamins25-hydroxyvitamin DCalcifediolCholestanetriol 26-MonooxygenaseCYP2R1 protein, humanCytochrome P450 Family 2GC protein, humanReceptors, CalcitriolVDR protein, humanVitamin DVitamin D-Binding ProteinVitamins25-OH vitamin DagingCYP2R1deficiencyelderlyGCgeneticssarcopeniaVDR

Identifiers

PMID36233147
PMCPMC9569711
OpenAlexW4303699655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.