ArticleInternational journal of molecular sciences2022
Targeting Phospholipase D Pharmacologically Prevents Phagocytic Function Loss of Retinal Pigment Epithelium Cells Exposed to High Glucose Levels.
Vicente Bermúdez, Paula Estefanía Tenconi, María Sol Echevarría, Aram Asatrian, Jorgelina Muriel Calandria, Norma María Giusto, Nicolas Guillermo Bazan, Melina Valeria Mateos
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors at 2 institutions in 2 countries.
Vicente BermúdezInstituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bahía Blanca 8000, Argentina.ORCID 0000-0001-9664-9899 Paula Estefanía TenconiInstituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bahía Blanca 8000, Argentina.ORCID 0000-0002-0440-5174 María Sol EchevarríaInstituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bahía Blanca 8000, Argentina.
Aram AsatrianNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.
Jorgelina Muriel CalandriaNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.
Norma María GiustoInstituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bahía Blanca 8000, Argentina.
Nicolas Guillermo BazanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA 70112, USA.
Melina Valeria MateosInstituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bahía Blanca 8000, Argentina.ORCID 0000-0003-0822-0975 Consejo Nacional de Investigaciones Científicas y Técnicas · ARLouisiana State University Health Sciences Center New Orleans · US
Funding
RPE Messengers, Transcription &Photoreceptor RenewalR01EY005121 · NEI · LSU HEALTH SCIENCES CENTER · PI Nicolas G. Bazan · 1985 to 2026
$9.1MAgencia Nacional de Promoción Científica y Tecnológica, Argentina PICT 2017-0350Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina PIP 2021-2023 11220200101062COEye Ear Nose & Throat Foundation of New Orleans No numberNational Eye Institute/National Institutes of Health R01EY005121NEI NIH HHS R01 EY005121Secretaría General de Ciencia y Tecnología, Universidad Nacional del Sur PGI 24/B308
6 · The paper itselfAbstract
We previously described the participation of canonical phospholipase D isoforms (PLD1 and PLD2) in the inflammatory response of retinal pigment epithelium (RPE) cells exposed to high glucose concentrations (HG). Here, we studied the role of the PLD pathway in RPE phagocytic function. For this purpose, ARPE-19 cells were exposed to HG (33 mM) or to normal glucose concentration (NG, 5.5 mM) and phagocytosis was measured using pHrodo™ green bioparticles
Indexed as
Phospholipase DCell LineCells, CulturedGlucoseHumansPhagocytosisRetinal Pigment EpitheliumGlucosePhospholipase Dinflammationoxidative stressphagocytosisphospholipase D (PLD)retinal pigment epithelium (RPE)
Identifiers
PMID36233124
PMCPMC9570224
OpenAlexW4303699672
What OpenQuestion holds
Textmetadata
LicenceCC BY
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