Evidence map›Paper›PMID 36233107›Full record

ReviewInternational journal of molecular sciences2022

A Review of Defatting Strategies for Non-Alcoholic Fatty Liver Disease.

Erin Nicole Young, Murat Dogan, Christine Watkins, Amandeep Bajwa, James D Eason, Canan Kuscu, Cem Kuscu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. In Vitro Models of Tissue and Organ Regeneration.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Key hepatoprotective roles of mitochondria in liver regeneration.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Erin Nicole YoungTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Murat DoganTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-0002-8428
Christine WatkinsTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Amandeep BajwaTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-0517-8871
James D EasonTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Canan KuscuTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-8043-7960
Cem KuscuTransplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-7154-6762
University of Tennessee Health Science Center · US

Funding

Off target mechanisms of kinase inhibitor toxicitiesR01DK132230 · NIDDK · OHIO STATE UNIVERSITY · PI BAJWA, AMANDEEP, PABLA, NAVJOT · 2022 to 2025
$2.0M
Mitochondrial Therapy for Kidney InjuryR01DK117183 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BAJWA, AMANDEEP · 2018 to 2022
$1.7M
James D. Eason Transplant Institute N/ANIDDK NIH HHS R01 DK117183NIDDK NIH HHS R01DK117183NIDDK NIH HHS R01 DK132230
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease is a huge cause of chronic liver failure around the world. This condition has become more prevalent as rates of metabolic syndrome, type 2 diabetes, and obesity have also escalated. The unfortunate outcome for many people is liver cirrhosis that warrants transplantation or being unable to receive a transplant since many livers are discarded due to high levels of steatosis. Over the past several years, however, a great deal of work has gone into understanding the pathophysiology of this disease as well as possible treatment options. This review summarizes various defatting strategies including in vitro use of pharmacologic agents, machine perfusion of extracted livers, and genomic approaches targeting specific proteins. The goal of the field is to reduce the number of necessary transplants and expand the pool of organs available for use.

Indexed as

Diabetes Mellitus, Type 2Liver TransplantationNon-alcoholic Fatty Liver DiseaseHumansLiverPerfusiondefattinglivermolecular biologysteatosis

Identifiers

PMID36233107
PMCPMC9569609
OpenAlexW4303699563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.