Evidence map›Paper›PMID 36233099›Full record

ArticleInternational journal of molecular sciences2022

The Importance of Toll-like Receptor 9 Expression on Monocytes and Dendritic Cells in the Context of Epstein-Barr Virus Infection in the Immunopathogenesis of Primary Glomerulonephritis.

Iwona Smarz-Widelska, Sebastian Mertowski, Paulina Mertowska, Izabela Korona-Głowniak, Anna Hymos, Ewelina Grywalska, Wojciech Załuska

Open access · goldAbstract read
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In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Iwona Smarz-WidelskaDepartment of Nephrology, Cardinal Stefan Wyszyński Provincial Hospital in Lublin, 20-718 Lublin, Poland.
Sebastian MertowskiDepartment of Experimental Immunology, Medical University of Lublin, 4a Chodźki Street, 20-093 Lublin, Poland.ORCID 0000-0002-7121-1396
Paulina MertowskaDepartment of Experimental Immunology, Medical University of Lublin, 4a Chodźki Street, 20-093 Lublin, Poland.ORCID 0000-0001-9530-6659
Izabela Korona-GłowniakDepartment of Pharmaceutical Microbiology, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland.ORCID 0000-0003-1634-0387
Anna HymosDepartment of Experimental Immunology, Medical University of Lublin, 4a Chodźki Street, 20-093 Lublin, Poland.
Ewelina GrywalskaDepartment of Experimental Immunology, Medical University of Lublin, 4a Chodźki Street, 20-093 Lublin, Poland.ORCID 0000-0002-0451-4741
Wojciech ZałuskaDepartment of Nephrology, Medical University of Lublin, 8 Jaczewskiego Street, 20-954 Lublin, Poland.ORCID 0000-0001-6043-3236
Medical University of Lublin · PL

Funding

Medical University of Lublin DS384, DS640, PBsd163, GI/1Polish National Science Centre UMO-2016/23/B/NZ6/02844
6 · The paper itself

Abstract

Toll-like receptor 9 (TLR9) is activated by unmethylated cytosine-phosphate-guanosine (CpG) dinucleotides found in the genomes of pathogens such as Epstein-Barr virus (EBV). The aim of this study was to determine the role of TLR9 in the immunopathogenesis of IgA nephropathy (IgAN) and membranoproliferative glomerulonephritis (MPGN) in the context of Epstein-Barr virus (EBV) infection. For this purpose, the frequency of TLR9-positive monocytes and dendritic cells (DCs, i.e., BDCA-1; myeloid dendritic cells, and BDCA-2; plasmocytoid dendritic cells) was studied, and a quantitative analysis of the concentration of TLR9 in the serum of patients diagnosed with IgAN and MPGN was undertaken. Higher frequencies of TLR9-positive DCs and monocytes in IgAN and MPGN patients were observed as compared with the control group. Patients diagnosed with GN exhibited a higher percentage of BDCA-1+CD19- and BDCA-2+CD123+ DCs than patients in the control group. Moreover, serum TLR9 concentration was shown to be significantly correlated with EBV DNA copy number/µg DNA, IgG, IgM, serum albumin, total protein in 24-h urine collection test and the frequency of BDCA-2+CD123+ DCs in peripheral blood. Our findings confirm that TLR9 may be involved in the development of IgAN and MPGN.

Indexed as

Epstein-Barr Virus InfectionsGlomerulonephritis, IGAGlomerulonephritis, MembranoproliferativeToll-Like Receptor 9CytosineDendritic CellsGuanosineHerpesvirus 4, HumanHumansImmunoglobulin GImmunoglobulin MInterleukin-3 Receptor alpha SubunitMonocytesPhosphatesSerum AlbuminCytosineGuanosineImmunoglobulin GImmunoglobulin MInterleukin-3 Receptor alpha SubunitPhosphatesSerum AlbuminTLR9 protein, humanToll-Like Receptor 9dendritic cellsEpstein–Barr virusglomerulonephritisIgA nephropathymembranoproliferative glomerulonephritismonocytesToll-like receptor 9

Identifiers

PMID36233099
PMCPMC9570264
OpenAlexW4303699586

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.