Evidence map›Paper›PMID 36233090›Full record

ReviewInternational journal of molecular sciences2022

Moderate-Risk Genes for Hereditary Ovarian Cancers Involved in the Homologous Recombination Repair Pathway.

Akiko Abe, Issei Imoto, Arisa Ueki, Hidetaka Nomura, Hiroyuki Kanao

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. The Genetic and Molecular Analyses of Rare Candidate GermlineInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Akiko AbeDepartment of Gynecologic Oncology, Cancer Institute Hospital of JFCR, Tokyo 135-8550, Japan.ORCID 0000-0002-0241-1319
Issei ImotoAichi Cancer Center Research Institute, Nagoya 464-8681, Japan.ORCID 0000-0002-4150-7938
Arisa UekiClinical Genetic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.ORCID 0000-0001-9205-5452
Hidetaka NomuraDepartment of Gynecologic Oncology, Cancer Institute Hospital of JFCR, Tokyo 135-8550, Japan.
Hiroyuki KanaoDepartment of Gynecologic Oncology, Cancer Institute Hospital of JFCR, Tokyo 135-8550, Japan.
The Cancer Institute Hospital · JPAichi Cancer Center · JPJapanese Foundation For Cancer Research · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 20% of cases of epithelial ovarian cancer (EOC) are hereditary, sharing many causative genes with breast cancer. The lower frequency of EOC compared to breast cancer makes it challenging to estimate absolute or relative risk and verify the efficacy of risk-reducing surgery in individuals harboring germline pathogenic variants (GPV) in EOC predisposition genes, particularly those with relatively low penetrance. Here, we review the molecular features and hereditary tumor risk associated with several moderate-penetrance genes in EOC that are involved in the homologous recombination repair pathway, i.e.,

Indexed as

Breast NeoplasmsOvarian NeoplasmsCarcinoma, Ovarian EpithelialFemaleGenetic Predisposition to DiseaseHomologous RecombinationHumansRecombinational DNA Repairepithelial ovarian cancergermline pathogenic varianthereditary tumorhomologous recombination repair pathwaymoderate risk

Identifiers

PMID36233090
PMCPMC9570179
OpenAlexW4303699344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.