Evidence map›Paper›PMID 36233064›Full record

ArticleInternational journal of molecular sciences2022

Mechanisms of Cd-Induced Cytotoxicity in Normal Human Skin Keratinocytes: Implication for Human Health.

Jing-Ya Li, Dao-Lei Cui, Yu-Mei Xie, Jin-Zhou Su, Meng-Yan Zhang, You-Ya Niu, Ping Xiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. The Effect and Molecular Mechanism ofCurrent issues in molecular biology · 2026
    Article
  2. Review
  3. Article
  4. Exploring the Functions of Mutant p53 throughCurrent issues in molecular biology · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jing-Ya LiYunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China.
Dao-Lei CuiYunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China.
Yu-Mei XieYunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China.
Jin-Zhou SuYunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China.
Meng-Yan ZhangYunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China.
You-Ya NiuSchool of Basic Medical Sciences, Hunan University of Medicine, Huaihua 418000, China.
Ping XiangYunnan Province Innovative Research Team of Environmental Pollution, Food Safety, and Human Health, Institute of Environmental Remediation and Human Health, School of Ecology and Environment, Southwest Forestry University, Kunming 650224, China.ORCID 0000-0002-0870-8551
Southwest Forestry University · CNHunan University · CN

Funding

National Natural Science Foundation of China 42067059, 21906134, 41967026Open Project of Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety KF-2020-01Research Foundation of Yunnan Education Department 2022J0508, 2021Y231, 2021Y237Top Young Talents Project of National Forestry and Grassland Administration 2020132613Yunnan Agricultural Basic Research Joint Special Project 202101BD070001-023Yunnan Fundamental Research Projects 202201AT070054, 2019FB014Yunnan Innovative Research Team 202005AE160017Yunnan Thousand Youth Talent Program YNQR-QNRC-2018-049
6 · The paper itself

Abstract

Cadmium (Cd) is one of the toxic heavy metals found widely in the environment. Skin is an important target organ of Cd exposure. However, the adverse effects of Cd on human skin are still not well known. In this study, normal human skin keratinocytes (HaCaT cells) were studied for changes in cell viability, morphology, DNA damage, cycle, apoptosis, and the expression of endoplasmic reticulum (ER) stress-related genes (

Indexed as

CadmiumEndoplasmic Reticulum StressApoptosisHumansKeratinocytesRNA, MessengerCadmiumRNA, Messengercadmium (Cd)cell apoptosiscell cycle arrestDNA damagegene expressionhuman skin keratinocytes

Identifiers

PMID36233064
PMCPMC9570009
OpenAlexW4303699589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.