Evidence map›Paper›PMID 36233010›Full record

ArticleInternational journal of molecular sciences2022

A Temporal Comparative RNA Transcriptome Profile of the Annexin Gene Family in the Salivary versus Lacrimal Glands of the Sjögren's Syndrome-Susceptible C57BL/6.NOD-

Ammon B Peck, Julian L Ambrus

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ammon B PeckDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, P.O. Box 100125, Gainesville, FL 32610, USA.
Julian L AmbrusDivision of Allergy, Immunology and Rheumatology, SUNY Buffalo School of Medicine, 875 Ellicott Street, Buffalo, NY 14203, USA.ORCID 0000-0003-4505-796X
University at Buffalo, State University of New York · USUniversity of Florida · US

Funding

Genetic Control of Autoimmune Exocrinopathy in NOD MiceR01DE014344 · NIDCR · UNIVERSITY OF FLORIDA · PI PECK, AMMON B · 2003 to 2007
$1.6M
Gene therapy targeting the Th17 / IL-27 system in autoimmune exocrinopathyR21AI081952 · NIAID · UNIVERSITY OF FLORIDA · PI PECK, AMMON B · 2009 to 2010
$403k
NIAID NIH HHS R21 AI081952NIDCR NIH HHS R01 DE014344
6 · The paper itself

Abstract

A generally accepted hypothesis for the initial activation of an immune or autoimmune response argues that alarmins are released from injured, dying and/or activated immune cells, and these products complex with receptors that activate signal transduction pathways and recruit immune cells to the site of injury where the recruited cells are stimulated to initiate immune and/or cellular repair responses. While there are multiple diverse families of alarmins such as interleukins (IL), heat-shock proteins (HSP), Toll-like receptors (TLR), plus individual molecular entities such as Galectin-3, Calreticulin, Thymosin, alpha-Defensin-1, RAGE, and Interferon-1, one phylogenetically conserved family are the Annexin proteins known to promote an extensive range of biomolecular and cellular products that can directly and indirectly regulate inflammation and immune activities. For the present report, we examined the temporal expression profiles of the 12 mammalian annexin genes (

Indexed as

AnnexinsLacrimal ApparatusSjogren's SyndromeThymosinAlarminsalpha-DefensinsAnimalsCalreticulinDisease Models, AnimalGalectin 3Heat-Shock ProteinsHumansInterferonsMiceMice, Inbred C57BLMice, Inbred NODAlarminsalpha-DefensinsAnnexinsCalreticulinGalectin 3Heat-Shock ProteinsInterferonsRNAThymosinannexinsAnxa genesC57BL/6.NOD-Aec1Aec2 mouseRNA transcriptome microarraySjögren’s syndrome

Identifiers

PMID36233010
PMCPMC9570365
OpenAlexW4303699746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.