Evidence map›Paper›PMID 36232958›Full record

ArticleInternational journal of molecular sciences2022

Human RAD51 Protein Forms Amyloid-like Aggregates

Daniel V Kachkin, Kirill V Volkov, Julia V Sopova, Alexander G Bobylev, Sergei A Fedotov, Sergei G Inge-Vechtomov, Oxana V Galzitskaya, Yury O Chernoff, Aleksandr A Rubel, Anna Y Aksenova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  3. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Daniel V KachkinLaboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.ORCID 0000-0002-2279-8514
Kirill V VolkovResearch Resource Center "Molecular and Cell Technologies", Research Park, St. Petersburg State University (SPbSU), 199034 St. Petersburg, Russia.ORCID 0000-0002-8027-5930
Julia V SopovaLaboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.ORCID 0000-0002-7825-273X
Alexander G BobylevInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 3 Institutskaya St., 142290 Moscow, Russia.ORCID 0000-0002-9477-1214
Sergei A FedotovLaboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.ORCID 0000-0002-7428-120X
Sergei G Inge-VechtomovDepartment of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia.
Oxana V GalzitskayaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 3 Institutskaya St., 142290 Moscow, Russia.ORCID 0000-0002-3962-1520
Yury O ChernoffSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332-2000, USA.ORCID 0000-0002-8934-9051
Aleksandr A RubelLaboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.ORCID 0000-0001-6203-2006
Anna Y AksenovaLaboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.ORCID 0000-0002-1601-1615
St Petersburg University · RUInstitute of Theoretical and Experimental Biophysics · RUGeorgia Institute of Technology · US

Funding

Russian Foundation for Basic Research 18-04-00799Russian Science Foundation 20-14-00148
6 · The paper itself

Abstract

RAD51 is a central protein of homologous recombination and DNA repair processes that maintains genome stability and ensures the accurate repair of double-stranded breaks (DSBs). In this work, we assessed amyloid properties of RAD51

Indexed as

DetergentsRad51 RecombinaseAmyloidAmyloidogenic ProteinsColoring AgentsGenomic InstabilityHumansProtein AggregatesAmyloidAmyloidogenic ProteinsColoring AgentsDetergentsProtein AggregatesRAD51 protein, humanRad51 Recombinaseamyloidamyloidogenesisfunctional amyloidsprotein aggregationprotein fibrilsRAD51X-ray diffraction

Identifiers

PMID36232958
PMCPMC9570251
OpenAlexW4303699525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.