Evidence map›Paper›PMID 36232930›Full record

ArticleInternational journal of molecular sciences2022

Tick-Borne Encephalitis Virus RNA Found in Frozen Goat's Milk in a Family Outbreak.

Eirini Mylonaki, Michael Seiberl, Neil Jones, Heike Bernhard, Ferdinand Otto, Georg Pilz, Eugen Trinka, Peter Wipfler

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eirini MylonakiDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Centre of Cognitive Neuroscience, 5020 Salzburg, Austria.
Michael SeiberlDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Centre of Cognitive Neuroscience, 5020 Salzburg, Austria.
Neil JonesDepartment of Paediatrics, Paracelsus Medical University, 5020 Salzburg, Austria.
Heike BernhardDepartment of Paediatrics, Paracelsus Medical University, 5020 Salzburg, Austria.
Ferdinand OttoDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Centre of Cognitive Neuroscience, 5020 Salzburg, Austria.
Georg PilzDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Centre of Cognitive Neuroscience, 5020 Salzburg, Austria.
Eugen TrinkaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Centre of Cognitive Neuroscience, 5020 Salzburg, Austria.
Peter WipflerDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Centre of Cognitive Neuroscience, 5020 Salzburg, Austria.ORCID 0000-0003-4982-4855
Paracelsus Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tick-borne encephalitis (TBE) is one of the commonest arthropod-borne viral diseases in Middle-East Europe and North Asia. The main reservoir of the virus is comprised of small rodents and domestic mammals with the common tick (Ixodes) being the usual vector. The clinical spectrum of TBE ranges from mild meningitis to severe meningoencephalomyelitis. This disease can lead to severe sequelae and has a mortality up to 2% in Europe. Even though the majority of cases are transmitted through bites of infected ticks, infections through ingestion of contaminated milk and dairy products from farms in endemic areas have been reported. We report a family outbreak of a febrile disease, initially suggestive of human-to-human infection, during the early summertime in Austria. Tick-borne encephalitis was diagnosed following consumption of unpasteurised goat's milk and the virus was subsequently detected in frozen milk samples. Although this is a rare manifestation of TBE, this case series shows that TBE should be included in the differential diagnosis of an outbreak of febrile disease, and a careful clinical history with reference to unpasteurized dairy products is crucial in order to prevent further disease spread. The best preventive measure is active immunisation of people living in, or travelling to, endemic areas.

Indexed as

Encephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneIxodesAnimalsDisease OutbreaksGoatsHumansMilkRNARNAalimentary infectionfood-borne transmissionmilk-borne infectionsTBE outbreakstick-borne encephalitis virus

Identifiers

PMID36232930
PMCPMC9570086
OpenAlexW4303699324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.