Evidence map›Paper›PMID 36232927›Full record

ArticleInternational journal of molecular sciences2022

Unveiling Targets for Treating Postoperative Pain: The Role of the TNF-α/p38 MAPK/NF-κB/Nav1.8 and Nav1.9 Pathways in the Mouse Model of Incisional Pain.

Flávia Oliveira de Lima, Pedro Santana Sales Lauria, Renan Fernandes do Espírito-Santo, Afrânio Ferreira Evangelista, Tâmara Magalhães Oliveira Nogueira, Dionéia Araldi, Milena Botelho Pereira Soares, Cristiane Flora Villarreal

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Flávia Oliveira de LimaHealth Department, State University of Feira de Santana, Feira de Santana 44036900, BA, Brazil.
Pedro Santana Sales LauriaSchool of Pharmacy, Federal University of Bahia, Salvador 40170115, BA, Brazil.
Renan Fernandes do Espírito-SantoGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 40296710, BA, Brazil.
Afrânio Ferreira EvangelistaSENAI Institute of Innovation in Advanced Health Systems, University Center SENAI/CIMATEC, Salvador 41650010, BA, Brazil.ORCID 0000-0001-8011-4128
Tâmara Magalhães Oliveira NogueiraGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 40296710, BA, Brazil.
Dionéia AraldiDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas 13083-862, SP, Brazil.ORCID 0000-0001-8379-2901
Milena Botelho Pereira SoaresGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 40296710, BA, Brazil.
Cristiane Flora VillarrealSchool of Pharmacy, Federal University of Bahia, Salvador 40170115, BA, Brazil.ORCID 0000-0002-0113-7864
Fundação Oswaldo Cruz · BRServiço Nacional de Aprendizagem Industrial · BRUniversidade Federal da Bahia · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Estadual de Feira de Santana · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado da Bahia APP0035/2016National Council for Scientific and Technological DevelopmentOswaldo Cruz Foundation
6 · The paper itself

Abstract

Although the mouse model of incisional pain is broadly used, the mechanisms underlying plantar incision-induced nociception are not fully understood. This work investigates the role of Na

Indexed as

Mitogen-Activated Protein Kinase 14NF-kappa BAnimalsCyclooxygenase 2Disease Models, AnimalGanglia, SpinalMaleMiceOligodeoxyribonucleotidesp38 Mitogen-Activated Protein KinasesPostoperative PainProstaglandins ESodium ChannelsTumor Necrosis Factor-alphaCyclooxygenase 2Mitogen-Activated Protein Kinase 14NF-kappa BOligodeoxyribonucleotidesp38 Mitogen-Activated Protein KinasesProstaglandins ESodium ChannelsTumor Necrosis Factor-alphaNF-κBp38 MAPKpostoperative painTNF-αvoltage-gated sodium channels

Identifiers

PMID36232927
PMCPMC9570460
OpenAlexW4303699532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.