ArticleInternational journal of molecular sciences2022
Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testicular Function.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Current risk factors for male infertility and semen parameters: an umbrella review of systematic reviews and meta-analyses.Asian journal of andrology · 2026Pooled it
- Moderate Intensity Exercise Training in Combination with L-Carnitine Ameliorates The Varicocele-Suppressed Self-Renewal; Implication onInternational journal of fertility & sterility · 2026Article
- Exercise attenuates inflammaging and testosterone decline in aged and morphine-treated rats: a role for NF-κB signaling.Biogerontology · 2025Article
- Optimal Exercise Intensity for Enhancing Sperm Parameters: A Network Meta-Analysis of Rodent Studies.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Research Progress on the Interaction Between SIRT1 and Mitochondrial Biochemistry in the Aging of the Reproductive System.Biology · 2025Review
- Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization.International journal of molecular sciences · 2025Article
- Effects of Physical Activity on Fertility Parameters: A Meta-Analysis of Randomized Controlled Trials.The world journal of men's health · 2024Article
- Smoking Induces a Decline in Semen Quality and the Activation of Stress Response Pathways in Sperm.Antioxidants (Basel, Switzerland) · 2023Article
- Expression Analysis of Molecular Chaperones Hsp70 and Hsp90 on Development and Metabolism of Different Organs and Testis in Cattle (Cattle-yak and Yak).Metabolites · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Aging is associated with testicular morphological and functional alterations, but the underlying molecular mechanisms and the impact of physical exercise are poorly understood. In this study, we examined the effects of age and lifelong moderate-intensity exercise on rat testis. Mature adults (35 weeks) and middle-aged (61 weeks) Wistar Unilever male rats were maintained as sedentary or subjected to a lifelong moderate-intensity treadmill training protocol. Testis weight and histology, mitochondrial biogenesis and function, and proteins involved in protein synthesis and stress response were evaluated. Our results illustrate an age-induced testicular atrophy that was associated with alterations in stress response, and mitochondrial biogenesis and function. Aging was associated with increased testicular levels of heat shock protein beta-1 (HSP27) and antioxidant enzymes. Aging was also associated with decreased mRNA abundance of the nuclear respiratory factor 1 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.