Evidence map›Paper›PMID 36232905›Full record

ArticleInternational journal of molecular sciences2022

The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 Are Important for Their Gap Junction Channel Ion Permeation and Gating.

Roa'a Jaradat, Xiaole Li, Honghong Chen, Peter B Stathopulos, Donglin Bai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Frontiers in cell and developmental biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Roa'a JaradatDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0002-5827-9070
Xiaole LiDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0002-3580-0417
Honghong ChenDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.
Peter B StathopulosDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0002-0536-6656
Donglin BaiDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0003-1112-6947
Western University · CA

Funding

CIHR 438225Natural Sciences and Engineering Research Council 05239Natural Sciences and Engineering Research Council 288141
6 · The paper itself

Abstract

Lens gap junctions (GJs) formed by Cx46 and Cx50 are important to keep lens transparency. Functional studies on Cx46 and Cx50 GJs showed that the V

Indexed as

Gap JunctionsIon Channel GatingConnexinsHydrophobic and Hydrophilic InteractionsIon ChannelsConnexinsIon Channelsamino terminal domainCx46Cx50gap junction structurepatch clampsingle channel conductanceVj-gating

Identifiers

PMID36232905
PMCPMC9570504
OpenAlexW4303699534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.