ArticleInternational journal of molecular sciences2022
Down-Regulation of Lipid Metabolism in the Hepatopancreas of Shrimp
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Microsporidia: evolution, infection mechanisms and host impact.Nature reviews. Microbiology · 2026Review
- Ecytonucleospora hepatopenaei causes lipid droplet depletion and imbalanced lipid metabolism in Penaeus vannamei.Scientific reports · 2025Article
- Host-Parasite Interactions and Integrated Management Strategies for Ecytonucleospora Hepatopenaei Infection in Shrimp.Acta parasitologica · 2025Review
- Influence of Buffer-Protected Sodium Butyrate Supplementation in the Diet ofAquaculture nutrition · 2025Article
- Microsporidia infection alters C. elegans lipid levels.PloS one · 2025Article
- Anti-Inflammatory, Antithrombotic, and Antioxidant Properties of Amphiphilic Lipid Bioactives from Shrimp.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Parasitic dinoflagellate Hematodinium in marine decapod crustaceans: a review on current knowledge and future perspectives.Parasitology research · 2023Review
- Article
- Dynamic Interplay of Metabolic and Transcriptional Responses in Shrimp during Early and Late Infection Stages ofInternational journal of molecular sciences · 2023Article
- Possible seasonal and diurnal modulation of Gammarus pulex (Crustacea, Amphipoda) drift by microsporidian parasites.Scientific reports · 2023Article
- Identification of Potential Druggable Targets and Structure-Based Virtual Screening for Drug-like Molecules against the Shrimp PathogenInternational journal of molecular sciences · 2023Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Enterocytozoon hepatopenaei (EHP) is the pathogen of hepatopancreatic microsporidiosis (HPM) in shrimp. The diseased shrimp Litopenaeus vannamei exhibits a slow growth syndrome, which causes severe economic losses. Herein, 4D label-free quantitative proteomics was employed to analyze the hepatopancreas of L. vannamei with a light (EHPptp2 < 103 copies/50 ng hpDNA, L group) and heavy (EHPptp2 > 104 copies/50 ng hpDNA, H group) load of EHP to better understand the pathogenesis of HPM. Exactly 786 (L group) and 1056 (H group) differentially expressed proteins (DEPs) versus the EHP-free (C group) control were mainly clustered to lipid metabolism, amino acid metabolism, and energy production processing. Compared with the L group, the H group exhibited down-regulation significantly in lipid metabolism, especially in the elongation and degradation of fatty acid, biosynthesis of unsaturated fatty acid, metabolism of α-linolenic acid, sphingolipid, and glycerolipid, as well as juvenile hormone (JH) degradation. Expression pattern analysis showed that the degree of infection was positively correlated with metabolic change. About 479 EHP proteins were detected in infected shrimps, including 95 predicted transporters. These findings suggest that EHP infection induced the consumption of storage lipids and the entire down-regulation of lipid metabolism and the coupling energy production, in addition to the hormone metabolism disorder. These were ultimately responsible for the stunted growth.
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