Evidence map›Paper›PMID 36232878›Full record

ArticleInternational journal of molecular sciences2022

Discovery and In Vivo Efficacy of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 4-(2-Aminoethyl)-

Mikhail Krasavin, Anatoly A Peshkov, Alexey Lukin, Kristina Komarova, Lyubov Vinogradova, Daria Smirnova, Evgeny V Kanov, Savelii R Kuvarzin, Ramilya Z Murtazina, Evgeniya V Efimova and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Mikhail KrasavinDepartment of Medicinal Chemistry, Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0002-0200-4772
Anatoly A PeshkovDepartment of Medicinal Chemistry, Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Alexey LukinLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Kristina KomarovaLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Lyubov VinogradovaLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Daria SmirnovaDepartment of Medicinal Chemistry, Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Evgeny V KanovInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Savelii R KuvarzinInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0002-9456-4717
Ramilya Z MurtazinaInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0001-5746-2204
Evgeniya V EfimovaInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0002-9641-515X
Maxim GureevCenter of Bio- and Chemoinformatics, Sechenov First Moscow State Medical University, Moscow 119435, Russia.ORCID 0000-0002-0385-922X
Kirill OnokhinInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Konstantin ZakharovAccellena Research and Development Inc., 88A Sredniy pr. V.O., Saint Petersburg 199106, Russia.ORCID 0000-0002-0557-0382
Raul R GainetdinovInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg 199034, Russia.
St Petersburg University · RUMIREA - Russian Technological University · RUSechenov University · RU

Funding

Russian Science Foundation 19-75-30008
6 · The paper itself

Abstract

Starting from a screening hit, a set of analogs was synthesized based on a 4-(2-aminoethyl)piperidine core not associated previously with trace amine-associated receptor 1 (TAAR1) modulation in the literature. Several structure-activity relationship generalizations have been drawn from the observed data, some of which were corroborated by molecular modeling against the crystal structure of TAAR1. The four most active compounds (EC

Indexed as

Dopamine Plasma Membrane Transport ProteinsPsychotic DisordersAnimalsDopaminePiperidinesRatsReceptors, G-Protein-CoupledTrace Amine-Associated ReceptorsDopamineDopamine Plasma Membrane Transport ProteinsPiperidinesReceptors, G-Protein-CoupledTrace Amine-Associated Receptorsagonistsantipsychoticbiogenic amine mimeticsdopamine transporter knockout ratshyperlocomotionmolecular modelingpsychotic disordersschizophreniatrace amine-associated receptor 1

Identifiers

PMID36232878
PMCPMC9569940
OpenAlexW4303699401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.