Evidence map›Paper›PMID 36232817›Full record

ArticleInternational journal of molecular sciences2022

What Do the Transcriptome and Proteome of Menstrual Blood-Derived Mesenchymal Stem Cells Tell Us about Endometriosis?

Letícia B C Penariol, Carolina H Thomé, Patrícia A Tozetti, Carlos R K Paier, Fabiana O Buono, Kamila C Peronni, Maristela D Orellana, Dimas T Covas, Maria E A Moraes, Wilson A Silva and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The interplay between endometriosis and obesity.Trends in endocrinology and metabolism: TEM · 2025
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  14. Downregulation ofInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Letícia B C PenariolDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.ORCID 0000-0002-3925-7407
Carolina H ThoméDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.
Patrícia A TozettiDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.
Carlos R K PaierDrug Research and Development Center, Federal University of Ceara, Ceará 60430-275, Brazil.
Fabiana O BuonoDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.
Kamila C PeronniDepartment of Genetics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.ORCID 0000-0002-8747-9282
Maristela D OrellanaRegional Blood Center, Medical School of Hemocenter Foundation of Ribeirão Preto, University of São Paulo, São Paulo 14051-140, Brazil.
Dimas T CovasRegional Blood Center, Medical School of Hemocenter Foundation of Ribeirão Preto, University of São Paulo, São Paulo 14051-140, Brazil.
Maria E A MoraesDrug Research and Development Center, Federal University of Ceara, Ceará 60430-275, Brazil.
Wilson A SilvaDepartment of Genetics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.ORCID 0000-0001-9364-2886
Júlio C Rosa-E-SilvaDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.ORCID 0000-0001-6930-1328
Rui A FerrianiDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.ORCID 0000-0001-9308-8344
Vitor M FaçaRegional Blood Center, Medical School of Hemocenter Foundation of Ribeirão Preto, University of São Paulo, São Paulo 14051-140, Brazil.ORCID 0000-0003-3205-7944
Omero B Poli-NetoDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.
Daniel G TiezziDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.
Juliana MeolaDepartment of Gynecology and Obstetrics, Medical School of Ribeirão Preto, University of São Paulo, São Paulo 14049-900, Brazil.ORCID 0000-0003-2514-4011
Universidade de São Paulo · BRNational Council for Scientific and Technological Development · BRUniversidade Federal do Ceará · BR

Funding

Institutos Nacionais de Ciência e Tecnologia INCT-CNPq 465482/2014-7São Paulo Research Foundation FAPESP 13/22431-3
6 · The paper itself

Abstract

Given the importance of menstrual blood in the pathogenesis of endometriosis and the multifunctional roles of menstrual mesenchymal stem cells (MenSCs) in regenerative medicine, this issue has gained prominence in the scientific community. Moreover, recent reviews highlight how robust the integrated assessment of omics data are for endometriosis. To our knowledge, no study has applied the multi-omics approaches to endometriosis MenSCs. This is a case-control study at a university-affiliated hospital. MenSCs transcriptome and proteome data were obtained by RNA-seq and UHPLC-MS/MS detection. Among the differentially expressed proteins and genes, we emphasize

Indexed as

EndometriosisMesenchymal Stem CellsCase-Control StudiesCell ProliferationFemaleHumansInterleukin-6LamininMechanistic Target of Rapamycin Complex 1MenstruationPhosphatidylinositol 3-KinasesProteomeProto-Oncogene Proteins c-aktTandem Mass SpectrometryTranscriptomeTransforming Growth Factor betaInterleukin-6LAMC3 protein, humanLamininMechanistic Target of Rapamycin Complex 1Phosphatidylinositol 3-KinasesProteomeProto-Oncogene Proteins c-aktTransforming Growth Factor betaendometriosisexpression profileMenSCsmenstrual bloodmulti-omics

Identifiers

PMID36232817
PMCPMC9570451
OpenAlexW4297988543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.