Evidence map›Paper›PMID 36232788›Full record

ArticleInternational journal of molecular sciences2022

Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway.

Umadevi Subramanian, Chandramohan Ramasamy, Samivel Ramachandran, Joshua M Oakes, Jason D Gardner, Kailash N Pandey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Renal Tubule Cell-SpecificHypertension (Dallas, Tex. : 1979) · 2026
    Article
  2. Article
  3. Deletion of ATAmerican journal of physiology. Renal physiology · 2024
    Article
  4. Podocyte cell-specificPhysiological genomics · 2024
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Umadevi SubramanianDepartment of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.
Chandramohan RamasamyDepartment of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.
Samivel RamachandranDepartment of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.
Joshua M OakesDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Jason D GardnerDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Kailash N PandeyDepartment of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.

Funding

Study of ANP Receptor:Gene Targeting and ExpressionR01HL062147 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1998 to 2020
$5.0M
ANP RECEPTOR--MOLECULAR APPROACH OF SIGNALING MECHANISMSR01HL057531 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1997 to 2013
$2.5M
ANP Receptor: Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Injury and DysfunctionR01DK133833 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 2022 to 2025
$1.8M
NHLBI NIH HHS R01 HL057531NHLBI NIH HHS R01 HL062147NIDDK NIH HHS R01 DK133833
6 · The paper itself

Abstract

The global targeted disruption of the natriuretic peptide receptor-A (NPRA) gene (

Indexed as

Guanylate CyclaseTransforming Growth Factor beta1ActinsAnimalsBenzamidesCollagenConnective Tissue Growth FactorFemaleFibrosisMaleMatrix Metalloproteinase 2MiceMonocyte Chemoattractant ProteinsNatriuretic PeptidesProliferating Cell Nuclear AntigenPyrazoles4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamideActinsatrial natriuretic factor receptor ABenzamidesCollagenConnective Tissue Growth FactorGuanylate CyclaseMatrix Metalloproteinase 2Monocyte Chemoattractant ProteinsNatriuretic PeptidesProliferating Cell Nuclear AntigenPyrazolesReceptors, Atrial Natriuretic FactorTransforming Growth Factor beta1Transforming Growth Factorscardiac fibrosisguanylyl cyclase receptorGW788388natriuretic peptidesSMADTGF-β1

Identifiers

PMID36232788
PMCPMC9569686

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.