Evidence map›Paper›PMID 36232769›Full record

ArticleInternational journal of molecular sciences2022

ZnT2 Is Critical for TLR4-Mediated Cytokine Expression in Colonocytes and Modulates Mucosal Inflammation in Mice.

Katherine McGourty, Ramya Vijayakumar, Tong Wu, Annie Gagnon, Shannon L Kelleher

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katherine McGourtyDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, 3 Solomont Way, Weed Hall 302, Lowell, MA 01852, USA.
Ramya VijayakumarDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, 3 Solomont Way, Weed Hall 302, Lowell, MA 01852, USA.
Tong WuDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, 3 Solomont Way, Weed Hall 302, Lowell, MA 01852, USA.ORCID 0000-0001-6829-6950
Annie GagnonDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, 3 Solomont Way, Weed Hall 302, Lowell, MA 01852, USA.
Shannon L KelleherDepartment of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, 3 Solomont Way, Weed Hall 302, Lowell, MA 01852, USA.
University of Massachusetts Lowell · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A wide range of microbial pathogens can enter the gastrointestinal tract, causing mucosal inflammation and infectious colitis and accounting for most cases of acute diarrhea. Severe cases of infectious colitis can persist for weeks, and if untreated, may lead to major complications and death. While the molecular pathogenesis of microbial infections is often well-characterized, host-associated epithelial factors that affect risk and severity of infectious colitis are less well-understood. The current study characterized functions of the zinc (Zn) transporter ZnT2 (

Indexed as

Cation Transport ProteinsColitisInflammationIntestinal MucosaToll-Like Receptor 4AnimalsCytokinesHT29 CellsHumansMiceMice, Inbred C57BLZincCation Transport ProteinsCytokinesTlr4 protein, mouseToll-Like Receptor 4ZincZnt2 protein, mousecolitiscolonocyteinflammationintestineTLR4zincZnT2

Identifiers

PMID36232769
PMCPMC9570081
OpenAlexW4297477325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.