Evidence map›Paper›PMID 36232749›Full record

ArticleInternational journal of molecular sciences2022

The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.

Magdalena Jastrzębska-Więsek, Magdalena Kotańska, Aleksandra Grzeszczak, Anna Jaromin, Maria Walczak, Anna Partyka, Joanna Gdula-Argasińska, Magdalena Smolik, Agnieszka Zagórska

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Magdalena Jastrzębska-WięsekDepartment of Clinical Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.ORCID 0000-0002-5388-1214
Magdalena KotańskaDepartment of Pharmacological Screening, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.ORCID 0000-0002-3946-1192
Aleksandra GrzeszczakDepartment of Lipids and Liposomes, Faculty of Biotechnology, University of Wrocław, 50-383 Wrocław, Poland.
Anna JarominDepartment of Lipids and Liposomes, Faculty of Biotechnology, University of Wrocław, 50-383 Wrocław, Poland.ORCID 0000-0002-7921-8007
Maria WalczakChair and Department of Toxicology, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.ORCID 0000-0002-5670-9866
Anna PartykaDepartment of Clinical Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Joanna Gdula-ArgasińskaDepartment of Radioligands, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.ORCID 0000-0003-3501-8350
Magdalena SmolikChair and Department of Toxicology, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Agnieszka ZagórskaDepartment of Medicinal Chemistry, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.ORCID 0000-0003-2510-7237

Funding

Funds for Statutory Activity of Jagiellonian University Medical College N42/DBS/000311National Science Center 2016/21/D/NZ7/01573
6 · The paper itself

Abstract

This study aimed to extend the body of preclinical research on prototype dual-acting compounds combining the pharmacophores relevant for inhibiting cyclic nucleotide phosphodiesterase 10 (PDE10A) and serotonin 5-HT

Indexed as

Brain-Derived Neurotrophic FactorDementiaAnimalsAntidepressive AgentsAntioxidantsBiological AvailabilityBlood GlucoseCholesterolDizocilpine MaleateHumansMemory DisordersNucleotides, CyclicPhosphoric Diester HydrolasesRatsRNA, MessengerSerotoninAntidepressive AgentsAntioxidantsBlood GlucoseBrain-Derived Neurotrophic FactorCholesterolDizocilpine MaleateNucleotides, CyclicPDE10A protein, humanPhosphoric Diester HydrolasesRNA, MessengerSerotoninTriglyceridescytotoxicitydementiadrug-like compoundsmultitarget compoundssafety pharmacology

Identifiers

PMID36232749
PMCPMC9569954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.