Evidence map›Paper›PMID 36232690›Full record

ArticleInternational journal of molecular sciences2022

Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from

Maria Laura Bellone, Lorenzo Fiengo, Carmen Cerchia, Roberta Cotugno, Ammar Bader, Antonio Lavecchia, Nunziatina De Tommasi, Fabrizio Dal Piaz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Exploring the Anticancer Potential ofPlants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Maria Laura BelloneDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.
Lorenzo FiengoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.
Carmen Cerchia"Drug Discovery" Laboratory, Department of Pharmacy, University of Napoli "Federico II", Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0002-6631-5000
Roberta CotugnoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.
Ammar BaderDepartment of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Mecca 21995, Saudi Arabia.ORCID 0000-0003-2201-7201
Antonio Lavecchia"Drug Discovery" Laboratory, Department of Pharmacy, University of Napoli "Federico II", Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0002-2181-8026
Nunziatina De TommasiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.
Fabrizio Dal PiazDepartment of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy.ORCID 0000-0002-8643-5018
University of Salerno · ITUniversity of Naples Federico II · ITUmm al-Qura University · SA

Funding

Regione Campania B61G18000470007
6 · The paper itself

Abstract

Human nucleolin (hNcl) is a multifunctional protein involved in the progression of various cancers and plays a key role in other pathologies. Therefore, there is still unsatisfied demand for hNcl modulators. Recently, we demonstrated that the plant ent-kaurane diterpene oridonin inhibits hNcl but, unfortunately, this compound is quite toxic for healthy cells. Trachylobane diterpene 6,19-dihydroxy-ent-trachiloban-17-oic acid (compound

Indexed as

AsteraceaeDiterpenesDiterpenes, KauraneNeoplasmsHumansLigandsNucleolinPhosphoproteinsPhosphorylationRNA-Binding ProteinsRNA, MessengerDiterpenesDiterpenes, KauraneLigandsNucleolinPhosphoproteinsRNA-Binding ProteinsRNA, Messengercancer cell apoptosisnucleolinplant diterpenespost-translational modificationprotein–drug interaction

Identifiers

PMID36232690
PMCPMC9570042
OpenAlexW4297538938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.