Evidence map›Paper›PMID 36232528›Full record

ArticleInternational journal of molecular sciences2022

Nicotinamide Mononucleotide Prevents Retinal Dysfunction in a Mouse Model of Retinal Ischemia/Reperfusion Injury.

Deokho Lee, Yohei Tomita, Yukihiro Miwa, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, Ken Nishioka, Kazuno Negishi, Jun Yoshino, Toshihide Kurihara

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Deokho LeeLaboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-5992-9039
Yohei TomitaLaboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0003-1013-5737
Yukihiro MiwaLaboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-5377-6772
Ari ShinojimaLaboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0003-2322-0332
Norimitsu BanDepartment of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
Shintaro YamaguchiDepartment of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-4917-033X
Ken NishiokaDepartment of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
Kazuno NegishiDepartment of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-2892-9810
Jun YoshinoDepartment of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
Toshihide KuriharaLaboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-5457-2720
Keio University · JP

Funding

JST SPRING JPMJSP2123KAKENHI 15 K10881KAKENHI 18 K09424
6 · The paper itself

Abstract

Retinal ischemia/reperfusion (I/R) injury can cause severe vision impairment. Retinal I/R injury is associated with pathological increases in reactive oxygen species and inflammation, resulting in retinal neuronal cell death. To date, effective therapies have not been developed. Nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD

Indexed as

Neuroprotective AgentsReperfusion InjuryAnimalsAntioxidantsDisease Models, AnimalInflammationIschemiaMiceNADNF-E2-Related Factor 2Nicotinamide MononucleotideReactive Oxygen SpeciesAntioxidantsNADNeuroprotective AgentsNF-E2-Related Factor 2Nicotinamide MononucleotideReactive Oxygen Speciesinflammationneuroprotectionnicotinamide mononucleotideoxidative stressretinal ischemia/reperfusion

Identifiers

PMID36232528
PMCPMC9570481
OpenAlexW4297154533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.