Evidence map›Paper›PMID 36232491›Full record

ArticleInternational journal of molecular sciences2022

Identification of a Novel Renal Metastasis Associated CpG-Based DNA Methylation Signature (RMAMS).

Jürgen Serth, Inga Peters, Olga Katzendorn, Tu N Dang, Joana Moog, Zarife Balli, Christel Reese, Jörg Hennenlotter, Alexander Grote, Marcel Lafos and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jürgen SerthDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Inga PetersDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Olga KatzendornDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Tu N DangDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Joana MoogDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Zarife BalliDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Christel ReeseDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Jörg HennenlotterDepartment of Urology, University of Tübingen, 72076 Tübingen, Germany.ORCID 0000-0003-3827-6996
Alexander GroteDepartment of Neurosurgery, University Hospital Gießen und Marburg, 35043 Marburg, Germany.
Marcel LafosDepartment of Pathology, Hannover Medical School, 30625 Hannover, Germany.
Hossein TezvalDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Markus A KuczykDepartment of Urology and Urologic Oncology, Hannover Medical School, 30625 Hannover, Germany.
Medizinische Hochschule Hannover · DEUniversitätsklinikum Gießen und Marburg · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 21% of patients with renal cell cancer (RCC) present with synchronous metastatic disease at the time of diagnosis, and metachronous metastatic disease occurs in 20-50% of cases within 5 years. Recent advances in adjuvant treatment of aggressive RCC following surgery suggest that biomarker-based prediction of risk for distant metastasis could improve patient selection. Biometrical analysis of TCGA-KIRC data identified candidate loci in the NK6 homeobox 2 gene (

Indexed as

Carcinoma, Renal CellKidney NeoplasmsBiomarkersCpG IslandsDNA MethylationHomeodomain ProteinsHumansBiomarkersHomeodomain ProteinsNKX6-2 protein, humanCpG-methylationDNA-methylationhypermethylationINAmetastasisNHLH2NKX6-2prognosisrenal cell carcinomasignatureTHBS4

Identifiers

PMID36232491
PMCPMC9569431
OpenAlexW4297236310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.