Evidence map›Paper›PMID 36232442›Full record

ArticleInternational journal of molecular sciences2022

Effects of RAGE Deletion on the Cardiac Transcriptome during Aging.

Francesco Scavello, Luca Piacentini, Stefania Castiglione, Filippo Zeni, Federica Macrì, Manuel Casaburo, Maria Cristina Vinci, Gualtiero I Colombo, Angela Raucci

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Glycation in the cardiomyocyte.Vitamins and hormones · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Francesco ScavelloUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0002-0297-0946
Luca PiacentiniBioinformatics and Artificial Intelligence Facility, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0003-1022-4481
Stefania CastiglioneUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0002-5999-8368
Filippo ZeniUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Federica MacrìUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Manuel CasaburoAnimal Facility, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.
Maria Cristina VinciVascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0001-6323-147X
Gualtiero I ColomboUnit of Immunology and Functional Genomics, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0002-7348-1939
Angela RaucciUnit of Experimental Cardio-Oncology and Cardiovascular Aging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.ORCID 0000-0003-1333-9671
Centro Cardiologico Monzino · IT

Funding

Fondazione IEO-Monzino Fellowship 2020Fondazione Veronesi Fellowship 2020Italian Ministry of Health Ricerca Corrente 2020-2022
6 · The paper itself

Abstract

Cardiac aging is characterized by increased cardiomyocyte hypertrophy, myocardial stiffness, and fibrosis, which enhance cardiovascular risk. The receptor for advanced glycation end-products (RAGE) is involved in several age-related diseases. RAGE knockout (

Indexed as

AgingTranscriptomeAnimalsFatty AcidsFemaleFibrosisGlycation End Products, AdvancedInterferon-betaMiceMice, Inbred C57BLMice, KnockoutReceptor for Advanced Glycation End ProductsTriglyceridesFatty AcidsGlycation End Products, AdvancedInterferon-betaReceptor for Advanced Glycation End ProductsTriglyceridesadaptive immunitycardioprotectionfibrosisRAGE isoformstranscriptome profiling

Identifiers

PMID36232442
PMCPMC9569842
OpenAlexW4296993936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.