Evidence map›Paper›PMID 36232425›Full record

ArticleInternational journal of molecular sciences2022

AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells.

Sundaramoorthy Revathidevi, Kazuyoshi Hosomichi, Toyoaki Natsume, Hirofumi Nakaoka, Naoko T Fujito, Hisako Akatsuka, Takehito Sato, Arasambattu Kannan Munirajan, Ituro Inoue

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sundaramoorthy RevathideviHuman Genetics Laboratory, National Institute of Genetics, Mishima 411-8540, Japan.
Kazuyoshi HosomichiLaboratory of Computational Genomics, Tokyo University of Pharmacy and Life Sciences, Hachioji 192-0392, Japan.
Toyoaki NatsumeMolecular Cell Engineering Laboratory, National Institute of Genetics, Mishima 411-8540, Japan.ORCID 0000-0002-3544-4491
Hirofumi NakaokaDepartment of Cancer Genome Research, Sasaki Institute, Sasaki Foundation, Chiyoda 101-0062, Japan.
Naoko T FujitoHuman Genetics Laboratory, National Institute of Genetics, Mishima 411-8540, Japan.
Hisako AkatsukaDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara 259-1193, Japan.ORCID 0000-0001-6094-4757
Takehito SatoDivision of Host Defense Mechanism, Tokai University School of Medicine, Isehara 259-1193, Japan.
Arasambattu Kannan MunirajanDepartment of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India.
Ituro InoueHuman Genetics Laboratory, National Institute of Genetics, Mishima 411-8540, Japan.
National Institute of Genetics · JPTokai University · JPSasaki Institute · JPTokyo University of Pharmacy and Life Sciences · JPUniversity of Madras · IN

Funding

Japan Agency for Medical Research and Development JP22ek0109484
6 · The paper itself

Abstract

Cowden syndrome (CS) is a rare autosomal dominant disorder associated with multiple hamartomatous and neoplastic lesions in various organs. Most CS patients have been found to have germline mutations in the

Indexed as

Hamartoma Syndrome, MultipleAnimalsBeclin-1Germ-Line MutationMutationPTEN PhosphohydrolaseRNA-Directed DNA PolymeraseTensinsZebrafishBeclin-1PTEN PhosphohydrolaseRNA-Directed DNA PolymeraseTensinsAMBRA1AMBRA1 Q30R mutantCowden syndromeCRISPR/CasG1/S transitionprimary cilia

Identifiers

PMID36232425
PMCPMC9570079
OpenAlexW4296617582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.