Evidence map›Paper›PMID 36232346›Full record

ArticleInternational journal of molecular sciences2022

The Autism Spectrum Disorder-Associated Bacterial Metabolite

Yuanpeng Zheng, Naika Z Prince, Lucia N Peralta Marzal, Sabbir Ahmed, Johan Garssen, Paula Perez Pardo, Aletta D Kraneveld

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Microglial phagocytosis in Alzheimer disease.Nature reviews. Neurology · 2026
    Review
  7. Review
  8. Article
  9. ACS pharmacology & translational science · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review of Elevated Para-Cresol in Autism and Possible Impact on Symptoms.International journal of molecular sciences · 2025
    Review
  15. UnravelingFrontiers in pharmacology · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuanpeng ZhengDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Naika Z PrinceDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Lucia N Peralta MarzalDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0003-1806-5382
Sabbir AhmedDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Johan GarssenDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-8678-9182
Paula Perez PardoDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Aletta D KraneveldDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0001-9819-383X
Utrecht University · NL

Funding

China Scholarship Council 201706210077European Commission, Horizon 2020 (call H2020-SC1-BHC-03-2018), GEMMA project Grant Agreement ID825033, www.gemma-project.eu
6 · The paper itself

Abstract

The bacterial metabolite 4-methylphenol (

Indexed as

ADAM ProteinsAutism Spectrum DisorderADAM10 ProteinADAM17 ProteinAmyloid Precursor Protein SecretasesAnimalsCresolsDisintegrinsGlucuronidesInterleukin-6LipopolysaccharidesMaleMembrane ProteinsMiceMicrogliaSulfates4-cresol4-cresol sulfateADAM10 ProteinAdam10 protein, mouseADAM17 ProteinAdam17 protein, mouseADAM ProteinsAmyloid Precursor Protein SecretasescresolCresolsDisintegrinsGlucuronidesInterleukin-6LipopolysaccharidesMembrane ProteinsSulfatesSulfuric Acid EstersTransforming Growth Factor beta1Tumor Necrosis Factor-alphaADAM10ADAM17autism spectrum disorderneuroimmune responsep-cresolp-cresyl sulfatevalproic acid

Identifiers

PMID36232346
PMCPMC9570133
OpenAlexW4296745929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.