Evidence map›Paper›PMID 36232222›Full record

ArticleInternational journal of environmental research and public health2022

Blue-Light-Blocking Lenses Ameliorate Structural Alterations in the Rodent Hippocampus.

Elizebeth O Akansha, Bang V Bui, Shonraj B Ganeshrao, Pugazhandhi Bakthavatchalam, Sivakumar Gopalakrishnan, Susmitha Mattam, Radhika R Poojary, Judith S Jathanna, Judy Jose, Nagarajan N Theruveethi

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Elizebeth O AkanshaDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal 576104, India.
Bang V BuiDepartment of Optometry & Vision Sciences, School of Health Sciences, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0001-7298-1352
Shonraj B GaneshraoDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal 576104, India.
Pugazhandhi BakthavatchalamDepartment of Anatomy, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal 576104, India.
Sivakumar GopalakrishnanDepartment of Physiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, India.
Susmitha MattamDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal 576104, India.
Radhika R PoojaryDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal 576104, India.
Judith S JathannaDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal 576104, India.
Judy JoseDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal 576104, India.
Nagarajan N TheruveethiDepartment of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal 576104, India.ORCID 0000-0003-1028-5807
Manipal Academy of Higher Education · INThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence suggests that prolonged blue-light exposure can impact vision; however, less is known about its impact on non-visual higher-order functions in the brain, such as learning and memory. Blue-light-blocking lenses (BBLs) claim to reduce these potential impacts. Hence, we assessed structural and functional hippocampal alterations following blue-light exposure and the protective efficacy of BBLs. Male Wistar rats were divided into (n = 6 in each group) normal control (NC), blue-light exposure (LE), and blue-light with BBLs (Crizal Prevencia, CP and DuraVision Blue, DB) groups. After 28 days of light exposure (12:12 light: dark cycle), rats were trained for the Morris water maze memory retention test, and brain tissues were sectioned for hippocampal neuronal analysis using Golgi and Cresyl violet stains. The memory retention test was significantly delayed (

Indexed as

HippocampusRodentiaAnimalsDendritesMaleNeuronsRatsRats, Wistarbehavior analysisblue-light blocking lenses (BBLs)hippocampuslight-emitting diodes (LEDs)retinal damage

Identifiers

PMID36232222
PMCPMC9564388
OpenAlexW4303946673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.