Evidence map›Paper›PMID 36231792›Full record

ReviewInternational journal of environmental research and public health2022

Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities.

Emmanuel A Ayeni, Ahmad M Aldossary, Daniel A Ayejoto, Lanre A Gbadegesin, Abdullah A Alshehri, Haya A Alfassam, Henok K Afewerky, Fahad A Almughem, Saidu M Bello, Essam A Tawfik

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Insights into the Diagnosis, Treatment, and Management of Prion Diseases.CNS & neurological disorders drug targets · 2026
    Review
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  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Heavy metal-induced disruption of the autophagy-lysosomal pathway: implications for aging and neurodegenerative disorders.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Emmanuel A AyeniChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.ORCID 0000-0002-9090-8674
Ahmad M AldossaryNational Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia.ORCID 0000-0003-0715-6780
Daniel A AyejotoDepartment of Industrial Chemistry, University of Ilorin, Ilorin 240003, Nigeria.ORCID 0000-0002-2846-7134
Lanre A GbadegesinUniversity of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-2364-9748
Abdullah A AlshehriNational Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia.ORCID 0000-0003-0358-4155
Haya A AlfassamKACST-BWH Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia.
Henok K AfewerkyDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0001-7030-3224
Fahad A AlmughemNational Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia.ORCID 0000-0001-9614-7557
Saidu M BelloInstitute of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary.ORCID 0000-0002-4482-1834
Essam A TawfikNational Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia.ORCID 0000-0003-0716-3251
King Abdulaziz City for Science and Technology · SAChinese Academy of Sciences · CNHuazhong University of Science and Technology · CNUniversity of Ilorin · NGUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal hormones and neurotransmitters are major determinant factors regulating brain structure and functions. The implications of environmental and climatic changes emerged recently as influence factors on numerous diseases. However, the complex interaction of neurotransmitters and neuronal hormones and their depletion under environmental and climatic influences on NDDs are not well established in the literature. In this review, we aim to explore the connection between the environmental and climatic factors to NDDs and to highlight the available and potential therapeutic interventions that could use to improve the quality of life and reduce susceptibility to NDDs.

Indexed as

Neurodegenerative DiseasesHormonesHumansNeurotransmitter AgentsQuality of LifeSignal TransductionHormonesNeurotransmitter Agentsclimateenvironmenthormonesneurodegenerative diseasesneurotransmitterspublic health

Identifiers

PMID36231792
PMCPMC9564880
OpenAlexW4303685932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.